阿奇霉素联合头孢西丁钠、替硝唑在盆腔炎中的治疗效果观察  

Effect observation of azithromycin combined with cefoxitin sodium and tinidazole in pelvic inflammatory diseases

作　　者：冯洁 高金宝 时友忠 安洪亮 FENG Jie;GAO Jin-bao;SHI You-zhong(Department of Pharmacy,Nanjing Meishan Hospital,Nanjing 210039,China)

机构地区：[1]南京梅山医院药剂科,210039

出　　处：《中国实用医药》2023年第14期113-115,共3页China Practical Medicine

摘　　要：目的研究盆腔炎患者采用阿奇霉素联合头孢西丁钠、替硝唑治疗的效果。方法98例盆腔炎患者,依据治疗方法不同分为观察组(45例)和对照组(53例)。观察组患者采用阿奇霉素联合头孢西丁钠、替硝唑治疗,对照组患者采用头孢西丁钠联合阿奇霉素或替硝唑治疗。比较两组患者疗效、临床症状复常时间、不良反应发生情况。结果观察组患者治疗总有效率为95.6%(43/45),对照组患者治疗总有效率为90.6%(48/53),两组患者治疗总有效率比较差异无统计学意义(P>0.05)。观察组患者的临床症状复常时间为10.0(7.0,11.0)d,明显长于对照组的8.0(5.5,10.0)d,差异具有统计学意义(P<0.05)。治疗期间,观察组患者的不良反应发生率略高于对照组,但差异无统计学意义(P>0.05)。结论阿奇霉素联合头孢西丁钠、替硝唑的治疗方案并不能增加临床的治疗有效率,也不能缩短患者临床症状复常时间,反而增加了不良反应的发生率。因此建议临床医生避免不必要的联合用药,以保证临床用药的安全。Objective To study the effect of azithromycin combined with cefoxitin sodium and tinidazole in pelvic inflammatory diseases.Methods A total of 98 patients with pelvic inflammatory disease were divided into observation group(45 cases)and control group(53 cases)according to different treatment methods.Patients in the observation group was treated with azithromycin combined with cefoxitin sodium and tinidazole,while patients in the control group was treated with cefoxitin sodium combined with azithromycin or tinidazole.The curative effect,the recovery time of clinical symptoms and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate was 95.6%(43/45)in the observation group and 90.6%(48/53)in the control group.There was no statistically statistical significance in the total effective rate between the two groups(P>0.05).The recovery time of clinical symptoms was 10.0(7.0,11.0)d in the observation group,which was significantly longer than that of 8.0(5.5,10.0)d in the control group,and the difference was statistically significant(P<0.05).During the treatment,the incidence of adverse reactions in the observation group was slightly higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion The combination of azithromycin,cefoxitin sodium and tinidazole can not increase the effective rate of clinical treatment,nor shorten the recovery time of clinical symptoms,but increase the incidence of adverse reactions.Therefore,clinicians are advised to avoid unnecessary combined administration in order to ensure the safety of clinical drug use.

关 键 词：盆腔炎 阿奇霉素 头孢西丁钠 替硝唑 症状复常时间 不良反应 

分 类 号：R711.33[医药卫生—妇产科学]