“变价”纳米递送系统在肿瘤治疗中的研究进展  

Research progress in valence-variable nano-delivery system in tumor treatment

作　　者：金哲妮 程苇钇 何莉 包丹丹 朴寄纲 JIN Zhe-ni;CHENG Wei-yi;HE Li;BAO Dan-dan;PIAO Ji-gang(School of Pharmacy,Zhejiang University of Chinese Medical,Hangzhou 310053;The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006)

机构地区：[1]浙江中医药大学药学院,杭州310053 [2]浙江中医药大学附属第一医院,杭州310006

出　　处：《中南药学》2023年第7期1846-1851,共6页Central South Pharmacy

基　　金：国家自然科学基金项目(No.82104405);浙江省自然科学基金项目(No.LY23H300002);浙江省中医药优秀青年人才基金项目(No.2021ZQ036)。

摘　　要：肿瘤严重危害人类身体健康,传统化疗等手段对正常细胞的生物相容性和高毒副作用等问题不容忽视,亟需寻找更为高效的治疗策略。金属及类金属基纳米材料因其具有良好的催化能力、理化特性已在肿瘤诊断和治疗中展现出良好的应用潜力。通过“变价”特性设计的纳米递送系统在实现药物靶向递送,提高抗肿瘤效果,降低毒副作用等方面展现出巨大优势。本文综述了各类“变价”纳米递送系统在肿瘤治疗中的进展和应用,以期为金属及类金属基纳米材料用于肿瘤治疗的进一步开发研究提供参考。Tumors are endangering human health.Biocompatibility problems and high toxic side effects on normal cells in traditional chemotherapy treatment cannot be ignored.It is urgent to find more efficient treatment strategies.Metal and metalloid nano-materials have shown potential in tumor diagnosis and treatment due to their good catalytic and physicochemical properties.Nano-delivery systems designed with valence-variable properties have shown obvious advantages of targeted drug delivery,improved anti-tumor effects,and reduced toxic effects.This paper reviewed the progress in various types of valence-variable nano-delivery systems in tumor therapy,to provide a reference for development of metal and metalloid-based nano-materials for tumor therapy.

关 键 词：纳米递送系统 毒副作用 多价态元素 肿瘤治疗 

分 类 号：R943[医药卫生—药剂学]