芳香烃受体在类风湿关节炎中作用及机制的研究进展  

Research progress in the role and mechanism of aryl hydrocarbon receptor for rheumatoid arthritis

作　　者：吕政伟 王宁 龚国清[1] LYU Zheng-wei;WANG Ning;GONG Guo-qing(School of Pharmacy,China Pharmaceutical University,Nanjing 211198)

机构地区：[1]中国药科大学药学院,南京211198

出　　处：《中南药学》2023年第7期1859-1864,共6页Central South Pharmacy

摘　　要：类风湿关节炎是一种自身免疫性疾病,其发病机制尚未完全明确,受基因、环境、免疫等多种因素影响。芳香烃受体是一种配体依赖性的转录因子,在免疫细胞功能调节和骨稳定中发挥重要功能。因此,研究芳香烃受体在类风湿关节炎中发挥作用的机制具有重要意义。本文就芳香烃受体在类风湿关节炎中的作用机制进行综述,并讨论基于芳香烃受体靶点治疗药物的发展情况。Rheumatoid arthritis is an autoimmune disease without clear mechanism,and its pathogenesis is influenced by various factors such as genes,environment and immunity.Aryl hydrocarbon receptor is a ligand-dependent transcription factor which plays an important role in the regulation of immune cells and bone stabilization.It is important to determine the relationship between aryl hydrocarbon receptor and rheumatoid arthritis.The role of aryl hydrocarbon receptor in rheumatoid arthritis and the progress of related drugs were discussed to provide evidence and ideas for future research.

关 键 词：芳香烃受体 类风湿关节炎 自身免疫性疾病 免疫细胞 

分 类 号：R96[医药卫生—药理学] R593.22[医药卫生—药学]