以科学思维提升为抓手的“生物化学”课程教学改革与探索  

Teaching Reform and Exploration of Biochemistry Course with Scientific Thinking Enhancement as Effective Means

作　　者：马红樱 MA Hongying(a.School of Medicine,b.Hubei Key Laboratory of Kidney Diseases Pathogenesis and Intervention,Hubei Polytechnic University,Huangshi Hubei 435003)

机构地区：[1]湖北理工学院医学院,湖北黄石435003 [2]湖北理工学院肾脏疾病发生与干预湖北省重点实验室,湖北黄石435003

出　　处：《湖北理工学院学报》2023年第4期57-60,共4页Journal of Hubei Polytechnic University

基　　金：湖北省教学改革研究项目(项目编号:2022437);湖北理工学院教学研究项目(项目编号:2020C40;2022A03)。

摘　　要：“生物化学”是医学专业的基础核心课程,其中蛋白质的结构和功能的关系是难点之一,也是理解生命的化学本质的基础。文章以Nav1.9和PRRT2蛋白知识点的讲授为例,通过阐述蛋白质二级结构α-螺旋稳定性的影响因素,促进学生理解蛋白质的构效关系。此外,通过课前向学生发布问题,指导学生自学文献、分组讨论、及时答疑,课中采用科学故事引入、学生展示讨论结果等教学环节,引导学生分析问题、解决问题,提高了学生的学习兴趣,强化了学习效果。基于科学问题驱动的深入学习,在激发学生学习兴趣的同时,有效培养了学生求真创新的科学精神。Biochemistry is one of the core courses in the medical profession,in which the relationship between the structure and function of proteins is one of the most difficult points,as well as the basis for understanding the chemical nature of life.The paper takes the teaching of Nav1.9 and PRRT2 proteins as an example to promote students′understanding of protein conformational relationships by elaborating the factors influencing the stability of theα-helix of protein secondary structure.In addition,students′interest in learning can be stimulated and the learning effect can be strengthened by issuing questions to students before class,guiding them to study the literature on their own,discuss in groups,and answer questions in a timely manner,and using teaching sessions such as the introduction of scientific stories and students′presentation of discussion results during class to guide students to analyze and solve problems.The in-depth learning driven by scientific problems has effectively cultivated students′scientific spirit of truth-seeking and innovation while stimulating their interest in learning.

关 键 词：“生物化学”课程 案例教学 α-螺旋稳定性 科学问题 

分 类 号：G642.0[文化科学—高等教育学]