无抗凝剂连续性肾脏替代治疗生理盐水冲洗体外循环回路的研究进展  

Research progress on saline flushing extracorporeal circulation line during continuous renal replacement therapy without anticoagulation

作　　者：孙献坤 王芳[2] 陈志文[2] 张凌[2] SUN Xiankun;WANG Fang;CHEN Zhiwen;ZHANG Ling(Department of Nephrology and Kidney Research Institute,West China Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Nephrology and Kidney Research Institute,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院肾脏内科/肾脏病研究所/四川大学华西护理学院,成都610041 [2]四川大学华西医院肾脏内科/肾脏病研究所,成都610041

出　　处：《华西医学》2023年第7期1073-1076,共4页West China Medical Journal

基　　金：四川省科技计划项目重点研发项目(2020YFG0105)。

摘　　要：现有抗凝剂可能存在相应的使用禁忌和副作用,以致于无抗凝剂连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)仍很常见。无抗凝剂CRRT虽不会造成严重的不良反应,但会增加凝血风险,进而导致治疗被迫中断。生理盐水冲洗体外循环管路作为非药物抗凝策略之一,被广泛应用。然而,在无抗凝剂CRRT过程中,它的临床效果尚存争议。因此,该文综述了在无抗凝剂CRRT时,生理盐水冲洗体外循环管路的具体方法、冲洗频率、冲洗效果、不良事件等,以为后续研究提供新思路。Because existing anticoagulants may have contraindications and side effects,continuous renal replacement therapy(CRRT)without anticoagulants is nevertheless widely used.Although it does not produce major adverse effects without anticoagulant CRRT,it can raise the risk of clotting,which can lead to treatment cessation.Extracorporeal circulation lines with saline flush are frequently utilized as a non-pharmaceutical anticoagulation strategy.However,in the absence of anticoagulant CRRT,its clinical efficacy remains debatable.Therefore,this article reviews the specific procedures,flushing frequency,flushing effect,and adverse events of flushing extracorporeal circulation lines with normal saline when CRRT is free anticoagulant,generating fresh ideas for future research.

关 键 词：连续性肾脏替代治疗 生理盐水冲洗 综述 

分 类 号：R459.5[医药卫生—治疗学]