蛋白A免疫吸附在自身免疫性疾病中的应用  

Immunoadsorption with Staphylococcus protein A column in autoimmune diseases

作　　者：杨莹莹[1] 张凌[1] YANG Yingying;ZHANG Ling(Department of Nephrology and Kidney Research Institute,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院肾脏内科/肾脏病研究所,成都610041

出　　处：《华西医学》2023年第7期1086-1090,共5页West China Medical Journal

摘　　要：蛋白A免疫吸附是一种借助葡萄球菌蛋白A能特异性与人体免疫球蛋白G高效结合的原理,通过体外循环的方法清除致病性抗体的血液净化治疗技术。目前已应用于多种自身免疫性疾病及器官移植排斥反应等领域,安全性较好,其对于多种免疫性疾病的疗效与传统血浆置换相当。该文就该技术在不同系统疾病中的应用进展作一综述,为临床治疗相关疾病时选择血液净化治疗模式提供参考。Immunoadsorption with Staphylococcus protein A column is a blood purification therapy that eliminates pathogenic antibodies on the principle that Staphylococcus protein A can specifically bind to human immunoglobin G efficiently.At present,it has been safely applied to a variety of autoimmune diseases and organ transplantation rejection and other fields.It has been reported to have efficacy for a variety of immune diseases,comparable to traditional plasma exchange.This article provides a review of the application progress of this technology in different systemic diseases,providing a reference for selecting blood purification treatment modes for clinical treatment of related diseases.

关 键 词：免疫吸附 蛋白A免疫吸附 自身免疫性抗体 自身免疫性疾病 

分 类 号：R593.2[医药卫生—内科学]