泄化浊瘀方联合依托考昔治疗痛风急性关节炎期患者的临床研究  

Clinical Study of Draining Turbidity Formula Combined with Etoricoxib in the Treatment of Patients with Acute Arthritis Stage of Gout

作　　者：储小敏 CHU Xiaomin(Department of Nephrology,people's Hospital of Daye City,Daye,Hubei 435100)

机构地区：[1]大冶市人民医院肾病内分泌科,湖北大冶435100

出　　处：《智慧健康》2023年第15期194-197,202,共5页Smart Healthcare

摘　　要：目的 探索泄化浊瘀方联合依托考昔治疗痛风急性关节炎期患者的临床疗效。方法 选择2022年3-6月在本科住院的痛风急性关节炎期患者65例,随机分为2组,试验组33例(泄化浊瘀方联合依托考昔组)和对照组32例(依托考昔组)。试验组给予依托考昔片120mg/日,联合泄化浊瘀方(劲牌持正堂颗粒方),每日1副,分早晚两次服用。对照组患者给予依托考昔片120mg/日。2组患者治疗7天后统计疗效。比较2组治疗前后监测白细胞、血沉、C反应蛋白、尿酸、尿PH值等指标,治疗前后中医症候评分,疼痛视觉模拟评分(VAS)变化情况。结果 试验组有效率高于对照组,差异有统计学意义(P<0.05)。试验组白细胞、血沉、C反应蛋白、血清尿酸水平下降较对照组更显著,差异有统计学意义(P<0.05)。试验组患者中医症候评分,关节疼痛VAS评分下降更明显,差异有统计学意义(P<0.05)。结论 泄化浊瘀方联合依托考昔治疗痛风急性关节炎期患者疗效显著,是目前临床上值得推荐的治疗方案。Objective To explore the clinical efficacy of draining turbidity formula combined with etonoxib in the treatment of patients with acute arthritis stage of gout.Methods A total of 65 patients with acute arthritis of gout who were hospitalized in our department from March 2022 to June 2022 were randomly divided into 2 groups,33 cases in the treatment group(draining turbidity formula combined with etoricoxib group)and 32 cases in the control group(etoricoxib group).The treatment group was given etoricoxib 120mg/day,combined with the discharge of turbidity(Jinpai Zhengtang granule formula),1 pair per day,divided into morning and evening two doses.The control group was given etoricoxib 120 mg/day orally.The efficacy of 2 groups of patients was calculated after 7 days of treatment.The two groups were compared with the monitoring of leukocytes,erythrocyte sedimentation rate,C-reactive protein,uric acid,urine PH value and other indexes,TCM syndrome score and pain visual simulation score(VAS)before and after treatment.Results The total effective rate of the experimental group was 96.9%,and the total effective rate of the control group was 84.4%,and the effective rate of the experimental group was higher than that of the control group,with a statistically significant difference(P<0.05).The levels of leukocytes,erythrocyte sedimentation rate,C-reactive protein and serum uric acid decreased significantly in the experimental group than in the control group,with statistically significant differences(P<0.05).In the experimental group,the syndrome score of joint pain decreased more significantly,and the difference was statistically significant(P<0.05).Conclusion Draining turbidity prescription combined with relying on coxib has a significant effect in the treatment of patients with acute arthritis of gout,and is currently a clinically recommended treatment plan.

关 键 词：泄化浊瘀方 依托考昔 痛风急性关节炎期 

分 类 号：R589.7[医药卫生—内分泌]