细小脲原体导致腹膜透析相关性腹膜炎1例  

Ureaplasma parvum-induced peritoneal dialysis-associated peritonitis: a case report

作　　者：谢超[1] 叶佩仪[1] 吴翠霞 誉翠颜[1] 孔耀中[1] Xie Chao;Ye Peiyi;Wu Cuixia;Yu Cuiyan;Kong Yaozhong(Department of Nephrology,the First People's Hospital of Foshan,Foshan 528000,China)

机构地区：[1]佛山市第一人民医院肾内科,佛山528000

出　　处：《中华肾脏病杂志》2023年第6期471-472,共2页Chinese Journal of Nephrology

摘　　要：病原体检出对改善腹膜透析相关性腹膜炎患者的预后非常重要。该文报道1例采用宏基因组二代测序(metagenomics next-generation sequencing,mNGS)技术诊断由细小脲原体导致的腹膜透析相关性腹膜炎病例。患者为中年女性,因腹痛伴透出液浑浊入院,头孢他啶联合万古霉素等抗感染治疗效果不佳,传统离心法培养未见细菌生长,采用mNGS技术检出细小脲原体,改用多西环素抗感染治疗后患者炎症得到控制,提示mNGS技术对常规培养阴性的腹膜透析相关性腹膜炎患者病原体的检出有重要价值。该文通过病例报道结合文献复习,为此类患者的诊治提供了临床经验。Pathogen detection is very important to improve the prognosis of patients with peritoneal dialysis-associated peritonitis.The paper reported a case of peritonitis caused by Ureaplasma parvum diagnosed by metagenomics next-generation sequencing(mNGS)technology.The patient was a middle-aged woman and hospitalized due to abdominal pain and muddy effluent.Anti-infective treatments such as ceftazidime and vancomycin were given but the effect was poor.The result of traditional culture was negative.Ureaplasma parvum was detected by mNGS.After using doxycycline,the patient's inflammation was controlled.It is suggested that mNGS plays an important role in the detection of the pathogens in peritoneal dialysis-associated peritonitis patients with negative culture.Through this case report and literature review,clinical experience is provided for the diagnosis and treatment in such patients.

关 键 词：脲原体属 腹膜透析 腹膜炎 宏基因组二代测序 病原菌 

分 类 号：R459.5[医药卫生—治疗学] R572.2[医药卫生—临床医学]