代谢组学在人体寄生虫病研究中的应用进展  

Advances in the application of metabolomics in the study of Human parasitic diseases

作　　者：赵云景 申艳梅 ZHAO Yunjing;SHEN Yanmei(iShandong Institute of Parasitic Diseases,Shandong First Medical University&Shandong Academy of Medical,Jining 272033,Shandong,China)

机构地区：[1]山东第一医科大学(山东省医学科学院),山东省寄生虫病防治研究所,山东第一医科大学附属消化病医院,山东济宁272033

出　　处：《中国病原生物学杂志》2023年第7期860-863,共4页Journal of Pathogen Biology

摘　　要：全世界有超过30亿人患有一种或多种寄生虫病,在大多数热带或亚热带国家,这些疾病很普遍,是人口发病和死亡的主要原因。人体寄生虫的多样性非常大,在大多数情况下,迫切需要更有效的新药。代谢组学包含各种蛋白质分离和鉴定技术,有助于识别代谢物(低分子质量生化化合物)以表征及生物体中生物途径,分析蛋白质之间的各种类型的相互作用及其进化谱系,是探索寄生虫与人体之间相互关系的有效工具。本文通过对代谢组学研究方法及其在人体寄生虫病的应用进行综述,为从代谢角度进行人体寄生虫病的早期诊断和治疗提供理论基础。More than 3 billion people worldwide suffer from one or more parasitic diseases,and in most tropical or subtropical countries,these diseases are prevalent and are a major cause of population morbidity and mortality.The diversity of human parasites is enormous,In most cases,new and more effective drugs are urgently needed.Metabolomics encompasses various protein isolation and identification techniques that help to identify metabolites(low molecular weight biochemical compounds)to characterize and biological pathways in organisms,to analyze various types of interactions between proteins and their evolutionary lineages,is An effective tool for exploring the interrelationship between parasites and the human body.This paper reviews the research methods of metabolomics and its application in human parasitic diseases,and provides a theoretical basis for the early diagnosis and treatment of human parasitic diseases from the perspective of metabolism.

关 键 词：人体寄生虫共患病 代谢组学 应用进展 诊断标志物 综述 

分 类 号：R38[医药卫生—医学寄生虫学]