肉苁蓉治疗阿尔茨海默病的作用机制研究进展  

Research Progress on Mechanism of Roucongrong(Herha Cistanches)in Treatment of Alzheimer's Disease

作　　者：武晓蓉 杨占君[1] 闫旭升[1] 贾建新[1] WU Xiaorong;YANG Zhanjun;YAN Xusheng;JIA Jianxin(Department of Human Anatomy,Baotou Medical College of Inner Mongolia University of Science and Technology,Baotou 014000,Inner Mongolia,China)

机构地区：[1]内蒙古科技大学包头医学院人体解剖学教研室,内蒙古包头014000

出　　处：《中华中医药学刊》2023年第6期106-110,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81860215);内蒙古自然科学基金项目(2021MS08010);包头医学院研究生科研创新项目(bycx2021005)。

摘　　要：肉苁蓉(Herha Cistanches)又名金笋、地精、习称、大芸,为列当科肉苁蓉属植物肉苁蓉的干燥带鳞叶的肉质茎,具有补肾阳、益精血、润肠通便等功效,为著名补益中药。现代药理学研究证实,肉苁蓉及其提取物具有显著的神经保护作用,可用于防治阿尔茨海默病(Alzheimer's disease,AD)、帕金森病(Parkinson's disease,PD)、亨廷顿病(Huntington's dis⁃ease,HD)、肌萎缩侧索硬化症(Amyotrophic lateral sclerosis,ALS)等神经退行性疾病。AD是一种常见的慢性疾病,主要发生在中老年人群中,随着人口老龄化,该病带来的各种负担愈发严重。目前,鲜有对肉苁蓉及其提取物防治AD的系统评价。现有实验研究发现,肉苁蓉及其提取物除了具有抗炎、抗氧化、抗神经元损伤、免疫调节作用、保护线粒体功能外,还有良好的降血糖活性,可以参与肠道菌群、自噬、性激素等生理调节。对肉苁蓉及其提取物在AD中的作用机制及治疗靶点的研究,将为临床提供新的治疗思路,具有重要意义。对肉苁蓉及其提取物的广泛生物活性展开综述,全面回顾了肉苁蓉及其提取物在防治AD中的可能作用机制,并提出几点展望。Roucongrong(Herha Cistanches),also known as golden bamboo shoots,goblins,commonly known as cistanches,is a dry,fleshy stem with scaly leaves of Cistanche,a plant of the genus Cistanche in the orobanceae.It has the effects of tonifying kidney Yang,benefiting essence and blood,moistening intestines and defecating,and is a famous tonic traditional Chinese medi⁃cine.Modern pharmacological studies have confirmed that Roucongrong(Herha Cistanches)and its extracts have significant neu⁃roprotective effects and can be used to prevent and treat neurodegenerative diseases such as alzheimer's disease(AD),parkinson's disease(PD),Huntington's disease(HD)and amyotrophic lateral sclerosis(ALS).AD is a common chronic disease,which main⁃ly occurs in the middle-aged and elderly population.With the aging of the population,the burden of the disease is becoming more and more serious.At present,there is little systematic evaluation on the prevention and treatment of AD by Roucongrong(Herha Cistanches)and its extracts.Existing experimental studies have found that Roucongrong(Herha Cistanches)and its ex⁃tracts not only have anti-inflammatory,anti-oxidation,anti neuronal damage,immune regulation and mitochondrial protection functions,but also have good hypoglycemic activity,which can participate in the physiological regulation of intestinal flora,autoph⁃agy,sex hormones and so on.The study on the mechanism and therapeutic targets of Roucongrong(Herha Cistanches)and its ex⁃tracts in AD will provide new therapeutic ideas for clinic,which is of great significance.This paper reviewed the extensive biolog⁃ical activities of Roucongrong(Herha Cistanches)and its extracts,comprehensively reviewed the possible mechanism of Roucon⁃grong(Herha Cistanches)and its extracts in the prevention and treatment of AD and put forward some prospects.

关 键 词：肉苁蓉 阿尔茨海默病 作用机制 

分 类 号：R277.749.16[医药卫生—中医学]