黄芪建中汤中药配方颗粒与传统饮片汤剂治疗慢性非萎缩性胃炎的临床疗效观察  

Clinical Effect of Dispensing Granules for Huangqi Jianzhong Decoction(黄芪建中汤)and Traditional Prepared Herbal Medicine Decoction on Chronic Non-Atrophic Gastritis

作　　者：刘二军[1] 邢亚情 张伟玲[1] 任首臣 郭庆丰 LIU Erjun;XING Yaqian;ZHANG Weiling;REN Shouchen;GUO Qingfeng(The First Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北医科大学第一医院,河北石家庄050000

出　　处：《中华中医药学刊》2023年第6期204-208,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省科技计划资助重点研发项目(223777141D)。

摘　　要：目的对比黄芪建中汤中药配方颗粒与传统饮片汤剂治疗慢性非萎缩性胃炎的临床疗效。方法选取2019年12月—2021年12月医院收治的102例慢性非萎缩性胃炎患者为研究对象,以随机数字表法分研究组、对照组,各51例。对照组给予黄芪建中汤传统汤剂,研究组给予黄芪建中汤中药配方颗粒,连续治疗3个月后观察效果。记录两组中医症状评分、胃镜检查评分、临床疗效,对比两组幽门螺杆菌转阴情况、炎症因子、药物安全性及用药满意度情况。结果两组治疗前、治疗后的主症、次症中医证候评分对比差异无统计学意义(P>0.05),两组治疗后的主症、次症中医证候评分均低于治疗前(P<0.05)。两组治疗前、治疗后的胃镜检查评分对比差异无统计学意义(P>0.05),两组治疗后的胃镜检查评分均低于治疗前(P<0.05)。研究组总有效率为96.08%(49/51),对照组总有效率为92.16%(47/51),两组总有效率比较差异无统计学意义(P>0.05)。两组幽门螺杆菌转阴率对比,差异无统计学意义(P>0.05)。两组治疗前、治疗后的白细胞介素(Interleukin,IL)-6、IL-8、IL-17水平对比差异均无统计学意义(P>0.05),两组治疗后的IL-6、IL-8、IL-17水平均低于治疗前(P<0.05)。研究组有3例出现不良事件,对照组有5例出现不良事件,两组总不良事件发生率比较差异无统计学意义(P>0.05)。研究组用药总满意率高于对照组(P<0.05)。结论黄芪建中汤中药配方颗粒与传统饮片汤剂治疗慢性非萎缩性胃炎疗效、安全性相当,但患者对黄芪建中汤中药配方颗粒满意度更高。Objective To compare the clinical efficacy of dispensing granules Huangqi Jianzhong Decoction(黄芪建中汤)and traditional prepare herbal decoction in treating chronic non-atrophic gastritis.Methods A total of 102 patients with chronic non-atrophic gastritis admitted to the hospital from December 2019 to December 2021 were selected as the research subjects and they were divided into study group and control group by random number table method,with 51 cases in each group.The control group was given traditional prepare herbal decoction of Huangqi Jianzhong Decoction,and the research group was given dispensing granules of Huangqi Jianzhong Decoction,and the effect was observed after continuous treatment for 3 months.The scores of tra⁃ditional Chinese medicine symptoms,gastroscopy and clinical efficacy were recorded.Helicobacter pylori negative conversion,in⁃flammatory factors,drug safety and drug satisfaction were compared between the two groups.Results There was no significant difference in the scores of traditional Chinese medicine syndromes of primary and secondary symptoms before and after treatment between the two groups(P>0.05),and the scores of traditional Chinese medicine syndromes of primary and secondary symptoms after treatment were lower than those before treatment(P<0.05).There was no significant difference between the two groups in the score of gastroscopy before and after treatment(P>0.05),and the score of gastroscopy after treatment was lower than that be⁃fore treatment(P<0.05).The total effective rate was 96.08%(49/51)in the study group and 92.16%(47/51)in the control group,with no significant difference(P>0.05).There was no significant difference in Helicobacter pylori negative conversion rate between the two groups(P>0.05).There were no significant differences in the levels of interleukin(IL)-6,IL-8 and IL-17 between two groups before and after treatment(P>0.05),and the levels of IL-6,IL-8 and IL-17 after treatment were lower than those before treatment(P<0.05).Adverse events occurred in 3

关 键 词：慢性非萎缩性胃炎 黄芪建中汤 配方颗粒 汤剂 疗效 安全性 满意度 

分 类 号：R259.733.2[医药卫生—中西医结合]