血清涎液化糖链抗原6对肺部疾病预警作用研究进展  

Research progress on the predictive role of serum Krebs von den Lungen-6 in pulmonary diseases

作　　者：朱雪华 秦亦如 农骐郢 黄永顺[2] 赵娜[2] 夏丽华[2] ZHU Xuehua;QIN Yiru;NONG Qiying;HUANG Yongshun;ZHAO Na;XIA Lihua(School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,China;不详)

机构地区：[1]中山大学公共卫生学院,广东广州510080 [2]广东省职业病防治院,广东广州510300

出　　处：《中国职业医学》2023年第1期104-109,共6页China Occupational Medicine

基　　金：国家自然科学基金(81903269);广东省自然科学基金(2021A1515012205,2021A1515010081,2021A1515011546);广东省医学科学技术研究基金(A2022013);广州市科技计划项目(202102080005);广东省职业病防治院重点科研项目(Z2022-11,Z2022-12)。

摘　　要：肺部疾病的早期诊断对于其防治具有重要意义。血清涎液化糖链抗原-6(KL-6)检测操作简便、无创、成本低,可反映肺泡上皮和间质的损伤程度。多种间质性肺疾病(如特发性肺纤维化和结缔组织病、原发性干燥综合征、类风湿关节炎、特发性炎症性肌病和系统性硬化合并间质性肺病)、非小细胞肺癌、多种肺炎和慢性阻塞性肺疾病患者的血清KL-6水平高于健康对照人群,对于上述疾病的早期诊断具有较好的灵敏度和特异度。职业性尘肺病是一种病因明确的间质性肺疾病。有研究结果显示,职业性矽肺患者、职业性石棉肺患者和粉尘作业工人血清KL-6水平均高于健康对照人群。但由于有关研究样本量少以及不同研究得出的结论并不一致,血清KL-6对于尘肺病早期诊断的价值仍需更多研究予以证实。未来需要增大样本量,改进血清KL-6检测方法,探讨其作为职业性肺部疾病早期诊断标志物的可行性,并探讨其与其他生物联合应用到包括职业性肺部疾病在内的更多的肺部疾病的早期诊断效能和应用价值,以充分发挥其对肺部疾病的预警作用。Early diagnosis of pulmonary diseases is of great significance for their prevention and treatment.Serum Krebs von den Lungen-6(KL-6) assay can reflect the damage degree of alveolar epithelium and stromal tissue,and is simple,non-invasive and low-cost.Pervious study showed that the serum KL-6 level was higher in patients with various interstitial lung diseases(e.g.idiopathic pulmonary fibrosis and connective tissue disease,primary Sj?gren′s syndrome,rheumatoid arthritis,idiopathic inflammatory myopathy and systemic sclerosis combined with interstitial lung disease),non-small cell lung cancer,various pneumonias and chronic obstructive pulmonary disease compared to healthy controls.Therefore,serum KL-6 has good sensitivity and specificity for the early diagnosis of these diseases.Occupational pneumoconiosis is an interstitial lung disease with a well-established etiology.Pervious study has shown that serum KL-6 level was higher in patients with occupational silicosis,occupational asbestosis,and dust-exposed workers compared to healthy controls.However,due to the limited sample size and the inconsistent findings on different studies,further research is needed to study the role of serum KL-6 in the early diagnosis of pneumoconiosis.Future studies should increase the sample size,improve the detection methods for serum KL-6,explore its feasibility as an early diagnostic biomarker for occupational pulmonary diseases,and investigate the efficacy andvalue of its combined application with other biomarkers in the early diagnosis of various pulmonary diseases,including occupational lung diseases,to fully exploit its predictive role in pulmonary diseases.

关 键 词：涎液化糖链抗原-6 诊断 生物标志物 间质性肺疾病 肺癌 肺炎 慢性阻塞性肺疾病 尘肺病 

分 类 号：R135.2[医药卫生—劳动卫生]