幽门螺旋杆菌疫苗研发研究进展  

Research progress of Helicobacter pylori vacine

作　　者：张颖[1] 李可心 毕艳娜 李晓亚 单保恩[1] 胡代伦[2] 赵连梅[1] ZHANG Ying;LI Kexin;BI Yanna;LI Xiaoya;SHAN Baoen;HU Dailun;ZHAO Lianmei(Scientific Research center,The Fourth Hospital,Hebei Medical University,Shijiazhuang O50000,China;Department of Pathogenic Biology,Hebei Medical University,Shijiazhuang O50000,China)

机构地区：[1]河北医科大学第四医院科研中心,河北石家庄050000 [2]河北医科大学病原生物学教研室,河北石家庄050000

出　　处：《细胞与分子免疫学杂志》2023年第6期564-570,共7页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(81772550);河北省杰出青年基金项目(H2019206697)。

摘　　要：幽门螺杆菌(Hp)是引起胃溃疡、十二指肠溃疡、胃癌等消化道疾病的主要致病菌,已经被世界卫生组织(WHO)列为Ⅰ类致癌因子。目前临床上主要使用抗生素和质子泵抑制剂联合治疗Hp,但随着Hp耐药性的逐年增加,Hp疫苗可能成为根除Hp的最终解决办法。尿素酶、毒力因子、外膜蛋白和鞭毛等成分在Hp感染、定殖和繁殖过程中发挥重要的作用,也成为Hp疫苗开发中潜在的候选抗原,以这些抗原为基础设计的疫苗在动物模型上取得了阶段性研究成果。我们总结了Hp疫苗的研究现状,以期为相关研究提供参考。Helicobacter pylori(Hp)is one of most common pathogens causing gastrointestinal disorder including gastric ulcer,duodenal ulcer and gastric cancer,etc.It has been verified as class I carcinogen by WHO.Nowadays,combination antibiotics and proton pump inhibitor are mainly used to erase Hp in clinical application.However,with the increased resistance of Hp,the vaccine against Hp might become the best strategy to eradicate Hp.Elements including urease,virulence factor,outer membrane protein,flagella,play an important role in Hp infection,colonization and reproduction.They have become potential candidate antigens in the development of Hp vaccine,as reported in previous studies.Presently,these antigens-centric vaccines have been tested in animal models.Therefore,this article reviews the studies on Hp vaccine with urease,virulence genes,outer membrane protein and flagella as their candidate antigens,in an attempt to provide insights forresearch inthis regard.

关 键 词：幽门螺杆菌(Hp) 尿素酶 毒力因子 鞭毛 外膜蛋白 疫苗 综述 

分 类 号：R186.3[医药卫生—流行病学] R735.2[医药卫生—公共卫生与预防医学] G353.11[文化科学—情报学]