新疆农村维吾尔族居民血清胱抑素C与代谢综合征的相关性及其性别差异  

Correlations between cystatin C and metabolic syndrome among rural Uygur in Xinjiang and gender-based difference

作　　者：何佳[1] 高鹏磊 杜威 廖贝宁 郭淑霞[1] 郭恒[1] 马儒林[1] 张向辉[1] 王馨平 李毓 HE Jia;GAO Penglei;DU Wei;LIAO Beining;GUO Shuxia;GUO Heng;MA Rulin;ZHANG Xianghui;WANG Xinping;LI Yu(Department of Preventive Medicine,School of Medicine,Shihezi University;School of Medicine,Shihezi University,Shihezi,Xinjiang 832002,China)

机构地区：[1]石河子大学医学院预防医学系 [2]石河子大学医学院,新疆石河子832002

出　　处：《中华高血压杂志》2023年第7期661-667,共7页Chinese Journal of Hypertension

基　　金：国家科技支撑计划(2009BAI82B04);石河子大学青年创新培育人才项目(CXPY202004);石河子大学校级科研立项(ZZZC202018A)。

摘　　要：目的探讨新疆农村维吾尔族居民的血清胱抑素C(Cys-C)与代谢综合征(MS)的关联性及其性别差异,为MS的防治提供参考。方法2010年7—8月采用分层整群随机抽样法抽取新疆喀什地区12个村18岁及以上的维吾尔族农村居民3775人,进行问卷调查、体格检查及实验室检查。比较研究人群不同MS组分下Cys-C水平的差异,同时利用多因素logistic回归分析血清Cys-C水平与MS的关联,采用受试者工作特征(ROC)曲线评价血清Cys-C对MS的判断价值。结果研究人群MS组Cys-C水平高于非MS组[(1.04±0.25)比(0.93±0.31)mg/L,t=-9.658,P<0.001]。按是否合并MS中的一种组分[腹型肥胖、高血糖、血压增高、三酰甘油升高、高密度脂蛋白胆固醇(HDL-C)降低]分组,除男、女性人群HDL-C降低组、男性人群高血糖组的Cys-C与相应对照组比较差异无统计学意义外,其余合并一种组分组的Cys-C水平均高于不合并该组分组(均P<0.001)。无论是MS还是非MS组,无论是否合并其中一种组分,男性Cys-C水平均高于女性。多因素logistic回归分析结果显示,调整混杂因素后,男性人群MS患病风险均随血清Cys-C水平升高呈增加趋势(χ^(2)=12.426,P_(趋势)=0.006),而在女性人群中此趋势并不显著。全人群Cys-C诊断MS的最佳临界值为0.87 mg/L,灵敏度为79.9%,特异度为41.8%;全人群、女性、男性Cys-C诊断MS的ROC曲线下面积(95%CI)分别为0.627(0.611~0.642),0.652(0.618~0.687),0.582(0.550~0.613),均P<0.001。结论新疆农村维吾尔族人群血清Cys-C与MS密切相关。男性人群MS患病风险随血清Cys-C水平升高呈增加趋势。Objective To assess the overall and sex-specific correlations between serum cystatin C(Cys-C)and metabolic syndrome(MS)among rural Uygur residents in Xinjiang,providing a reference for the prevention and treatment of MS.Methods From July to August 2010,3775 rural Uygur residents aged 18 and above were selected from 12 villages in Kashgar,Xinjiang by stratified cluster random sampling.Data were collected by questionnaire survey,physical examination and laboratory test.The serum Cys-C level was compared between the residents with different MS components.The correlation between serum Cys-C and MS was analyzed by multivariate logistic regression analysis.The receiver operating characteristic(ROC)curve was applied to assess the predictive value of Cys-C for MS.Results Among all participants,the MS group showed a higher level of Cys-C than the non-MS group[(1.04±0.25)vs(0.93±0.31)mg/L,t=-9.658,P<0.001].The subjects with one of the components of MS Labdominal obesity,hyperglycemia,increased blood pressure,elevated triacylglycerol and decreased high density lipoprotein cholesterol(HDL-C)J showed higher Cys-C levels than those without(P<O.01 for all),except for males and females with reduced HDL-C and males with hyperglycemia.Males showed higher levels of Cys-C than females regardless of the prevalence of MS or one of its components.After adjusting for confounders,multivariate logistic regression analysis showed that the risk of MS increased with the level of serum Cys-C in males(χ^(2)=12.426 P=0.006),but this trend was not significant among females.The optimal cutoff value of serum Cys-C for predicting MS in all participants was 0.87 mg/L,which yielded a sensitivity of 79.9%and a specificity of 41.8%.And the values of the area under the ROC curve(95%CI)for Cys-C predicting MS in all participants,females and males were 0.627(0.611-0.642),0.652(0.618-0.687),and 0.582(0.550-0.613),respectively(all P<0.001).Conclusions Cys-C is closely related to MS in rural Uygur in Xinjiang.The risk of MS in males increases with the inc

关 键 词：农村 维吾尔族 胱抑素C 代谢综合征 性别 

分 类 号：R589[医药卫生—内分泌]