早产儿高氧暴露与肾脏发育关系的研究进展  

Progress on the relationship between hyperoxia exposure and renal development in premature infants

作　　者：邓欢(综述) 张雅茹(综述) 郭耀(综述)[1] 由凯(审校)[1] Deng Huan;Zhang Yaru;Guo Yao;You Kai(Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院儿科,沈阳110004

出　　处：《国际儿科学杂志》2023年第6期374-377,共4页International Journal of Pediatrics

基　　金：国家自然科学基金青年基金(81501292);中国博士后基金面上项目(2017M611285);辽宁省基础研究计划(2022JH2/101500053)。

摘　　要：氧疗是临床改善早产儿氧合常见的治疗手段,但长时间高氧暴露会造成未成熟器官损伤及发育异常。除支气管肺发育不良和视网膜病外,高氧还可增加早产儿成年后患慢性肾脏疾病及高血压的风险。高氧暴露会导致早产儿肾脏损伤及发育异常,表现为肾小球数量减少、体积增大,肾脏细胞凋亡,肾小管发育异常,机制可能与肾脏发育相关信号通路异常相关。该文就高氧与肾脏发育的关系及其导致肾脏疾病的可能机制做一综述,以便为临床早期干预提供理论依据。Oxygen therapy is a common therapeutic method to improve oxygenation of premature infants,but long-term exposure to high oxygen can cause damage to immature organs and abnormal development.In addition to bronchopulmonary dysplasia and retinopathy,high oxygen levels will increase the risk of chronic kidney disease and hypertension in adulthood.High oxygen exposure can lead to kidney damage and developmental abnormalities in premature infants,including reduced number and increased volume of glomeruli,renal cell apoptosis,and abnormal development of renal tubules.The mechanism may be related to abnormal signaling pathways related to renal development.This article reviews the relationship between hyperoxia and kidney development and the possible mechanism of kidney disease,in an attempt to provide theoretical reference for early clinical intervention.

关 键 词：婴儿 早产 高氧 肾脏发育 肾脏损伤 

分 类 号：R722.6[医药卫生—儿科]