龙胆水提物中化学成分的分离与结构鉴定  

Isolation and identification of chemical constituents from the aqueous extract of Gentiana scabra Bge.

作　　者：来佳馨 吴肸乐 李世伟 何如尚 戴肃芳 张丽花 吴红华[1] LAI Jia-xin;WU Xi-le;LI Shi-wei;HE Ru-shang;DAI Su-fang;ZHANG Li-hua;WU Hong-hua(State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学组分中药国家重点实验室,天津301617

出　　处：《中国药物化学杂志》2023年第6期458-464,共7页Chinese Journal of Medicinal Chemistry

基　　金：天津市科技计划项目-中央引导地方科技发展专项(21ZYJDJC00080)。

摘　　要：目的对龙胆干燥的根及根茎的水提取物进行化学成分研究。方法采用多种色谱法对龙胆干燥的根及根茎的水提取物的化学成分进行分离纯化,并结合理化性质与波谱解析等方法进行结构鉴定。结果与结论从龙胆干燥的根及根茎的水提取物中分离鉴定出12个化合物,分别为橄榄苦苷(1)、獐芽菜苦苷(2)、龙胆苦苷(3)、獐芽菜苷(4)、2′-(2,3-二羟基苯甲酰)獐芽菜苷(5)、3′-乙酰基獐芽菜苷(6)、6′-乙酰基獐芽菜苷(7)、deglucogelidoside(8)、(1S,5R,9R)-deglucosyltrifloroside(9)、2,2′-氧代双(1,4)-二叔丁苯(10)、去氢吐叶醇(11)和9-epi-blumenol C(12)。其中,化合物1、10和11为首次从龙胆属植物中分离得到,化合物12为首次从该种植物中分离得到。To study the water-soluble chemical constituents of Gentiana scabra Bge.,various chromatographic methods were applied for the separation and purification of the aqueous extract of the dried roots and rhizomes of G.scabra.As the result,twelve compounds were obtained and identified by combining various spectroscopic methods with their physicochemical properties.These compounds were identified as oleuropein(1),swertiamarin(2),gentiopicroside(3),sweroside(4),2'-(2,3-dihydroxybenzoyl)swertiamarin(5),3'-0-acetylsweroside(6),6'-0-acetylsweroside(7),deglucogelidoside(8),(1S,5R,9R)-deglucosyltrifloroside(9),2,2'-oxybis(1,4)-di-tert-butylbenzene(10),(+)-dehydrovomifoliol(11),and 9-epi-blumenol C(12).Among them,compounds 1,10 and 11 were isolated from Gentiana for the first time,while compound 12 was previously undescribed from the plant of G.scabra.

关 键 词：龙胆 环烯醚萜类成分 提取分离 结构鉴定 

分 类 号：R284[医药卫生—中药学]