A versatile 3D-printable hydrogel for antichondrosarcoma,antibacterial,and tissue repair  

作　　者：Wenxiang Zhu Zheng Zhou Yuting Huang Hairong Liu Ning He Xiaolong Zhu Xiaoxiao Han Dengming Zhou Xuanchu Duan Xin Chen Yahui He Xiaolin Meng Shuai Zhu 

机构地区：[1]College of Materials Science and Engineering,Hunan University,Changsha 410082,China [2]College of Biology,Hunan University,Changsha 410082,China [3]State Key Laboratory of Advanced Design and Manufacture for Vehicle Body,Hunan University,Changsha 410082,China [4]Department of Ophthalmology,The Second Xiangya Hospital,Central South University,Changsha 410011,China [5]Aier Glaucoma Institute,Changsha 410000,China [6]Aier School of Ophthalmology,Central South University,Changsha 410000,China [7]Changsha Aier Eye Hospital,Aier Eye Hospital Group,Changsha 410000,China

出　　处：《Journal of Materials Science & Technology》2023年第5期200-211,共12页材料科学技术（英文版）

基　　金：This work was supported by The National Key Research and De-velopment Program of China(No.2018YFC1105800);the Natural Science Foundation of Hunan province(No.2021JJ30095);the Natural Science Foundation of Changsha City(No.Z202169480188).

摘　　要：Following operative treatment of chondrosarcoma,post-surgery tissue reconstruction may be confronted with daunting challenges,including the delayed self-repair of defective tissue,tumor recurrence,and bac-terial infection.To overcome these challenges,a methacrylic anhydride(MA)modified sericin(SerMA)solution mixed with procyanidins(PC)loaded polydopamine(PDA)modified ZIF-8(PC@ZIF-8@PDA)nanoparticles to form a multifunctional PC@ZIF-8@PDA/SerMA hydrogel after exposure under blue light.Hydrogel products with pre-designed shapes were printed out by using the SerMA solution carrying PC@ZIF-8@PDA nanoparticles and chondrocytes,indicating that PC@ZIF-8@PDA/SerMA hydrogels with personalized shapes can be fabricated via 3D printing.Photocrosslinked PC@ZIF-8@PDA/SerMA hydrogel is able to kill chondrosarcoma cells and bacteria,like Staphylococcus aureus(S.aureus),and Escherichia coli(E.coli),by its photothermal activity combined with near-infrared radiation(NIR).The PC@ZIF-8@PDA/SerMA hydrogel exhibited an antioxidative activity and a good biocompatibility and was easily monitored by its florescent and photoacoustic properties.Rabbit articular cartilage defects were efficiently repaired by PC@ZIF-8@PDA/SerMA hydrogels with encapsulated corresponding autologous chondrocytes,and mice skin burning wounds were swiftly regenerated by applying this hydrogel.Hence,the PC@ZIF-8@PDA/SerMA hydrogel can be potentially applied to the clinic treatment of chondrosarcoma and tissue defect repair after chondrosarcoma resection due to its multifunction in the future.

关 键 词：HYDROGEL SERICIN ZIF-8 CHONDROSARCOMA Cartilage repair 

分 类 号：R318.08[医药卫生—生物医学工程]