钌(Ru)修饰的锆基金属有机框架材料(Zr-MOF)催化酰胺化反应  

Ruthenium(Ru)Modified Zirconium-based Organometallic Framework Material(Zr-MOF)for Catalytic Amidation Reaction

作　　者：黄飞鸿 王乐 张朋飞 Huang Feihong;Wang Le;Zhang Pengfei(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201600,China)

机构地区：[1]东华大学材料科学与工程学院纤维材料改性国家重点实验室,上海201600

出　　处：《山东化工》2023年第11期9-12,共4页Shandong Chemical Industry

摘　　要：含氮分子广泛存在于各种药物分子、生物大分子、药物中间体和功能材料中,而酰胺键的构建是引入氮原子的绝佳途径。目前,合成酰胺键的方法在很大程度上取决于偶联剂的选择和贵金属的残留。在这里,报道了一个一锅反应,在光照条件下,PCN-808-Ru用作多相催化剂,原位生成酰氯官能团,然后与胺反应以有效合成酰胺。该方法具有产率高、催化剂回收率高、产物分离步骤简单等优点。Nitrogen-containing molecules widely exist in various pharmaceutical molecules,biological macromolecules,pharmaceutical intermediates and functional materials,and the construction of amide bonds is an excellent way to introduce nitrogen atoms.At present,the methods of synthesizing amide bonds depend heavily on the selection of coupling reagents and the residue of precious metals.Here we report a one-pot reaction,under light conditions,PCN-808-Ru is used as a heterogeneous catalyst to generate acyl chloride functional bodies in situ,and then react with amines to efficiently synthesize amides.This method has the advantages of high yield,excellent catalyst recycling and simple product separation steps.

关 键 词：MOFs催化 酰胺化 C-H胺化 

分 类 号：TQ201[化学工程—有机化工] O621.25[理学—有机化学]