二氧化锰纳米复合材料的合成及其在肿瘤治疗中的应用进展  

The Synthesis of Manganese Dioxide Nanocomposites and Their Applicationfor Tumor Therapy

作　　者：陈艾红 张子文 周诺馨 夏玮 邝运起 赵琳静[1] 陆杰 罗宇 刘锡建[1] Chen Aihong;Zhang Ziwen;Zhou Nuoxin;Xia Wei;Kuang Yunqi;Zhao Linjing;Lu Jie;Luo Yu;Liu Xijian(School of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620,China)

机构地区：[1]上海工程技术大学化学化工学院,上海201620

出　　处：《山东化工》2023年第11期78-81,共4页Shandong Chemical Industry

基　　金：国家自然科学基金(21978165,92156020);上海市大学生创新项目(cs2204002)。

摘　　要：恶性肿瘤是造成人们死亡的一个主要因素,纳米科技的发展为肿瘤治疗提供了新的方式。其中纳米二氧化锰(MnO_(2))复合材料在肿瘤的治疗具有显著的优势,在肿瘤环境中能够发生芬顿反应诱导肿瘤细胞死亡、消耗还原性的谷胱甘肽(GSH)和生成氧气改善肿瘤乏氧环境等。文章介绍了几种常见的MnO_(2)纳米材料的制备方法,包括模板法、水热法和溶胶凝胶法;其次,对二氧化锰纳米材料在光动力治疗(PDT)、化学动力学治疗(CDT)、声动力治疗(SDT)、化疗等方面的应用进行了综述,讨论了目前MnO_(2)纳米材料的研究现状以及不足,并展望了其研究发展方向和在临床上的应用前景。Malignant tumor is one of the main causes of death in the world.Due to the rapid development of nanotechnology,tumor therapy have new method.The nano manganese dioxide(MnO_(2))has prominent advantages for tumor therapy,such as occur Fenton reaction in tumor environment to induce tumor cell death,consume reducing glutathione(GSH)and generate oxygen to improve the hypoxic environment of tumor.In this paper,the preparation methods of MnO_(2) nanomaterials include template method,hydrothermal method and sol-gel method were introduced.Secondly,the applications of MnO_(2) nanocomposites in photodynamic therapy,chemical dynamic therapy,sonodynamic therapy and chemical therapy are reviewed.Finally,the research status and deficiency of MnO_(2) nanomaterials are discussed,and their study and application prospect is prospected.

关 键 词：二氧化锰 肿瘤治疗 化学动力治疗 光动力治疗 

分 类 号：TQ137.1[化学工程—无机化工]