紫草外用传统制剂与新型纳米制剂的研究进展  

Research progress of traditional external preparations and novel nanoformulations of Arnebiae Radix

作　　者：杨小瑜 姜一平 冯浩维 舒余琪 廖树怡 廖燕 邵萌 YANG Xiaoyu;JIANG Yiping;FENG Haowei;SHU Yuqi;LIAO Shuyi;LIAO Yan;SHAO Meng(Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics,School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;Dept.of Pharmacy,Zhuhai People’s Hospital,Guangdong Zhuhai 519070,China;Dept.of Pharmacy,General Hospital of the Third Division of Xinjiang Production and Construction Corps,Xinjiang Tumushuk 843900,China)

机构地区：[1]南方医科大学中医药学院广东省中药制剂重点实验室,广州510515 [2]珠海市人民医院药学部,广东珠海519070 [3]新疆生产建设兵团第三师总医院药剂科,新疆图木舒克843900

出　　处：《中国药房》2023年第15期1909-1914,共6页China Pharmacy

基　　金：广东省自然科学基金资助项目(No.2023A1515011111);广东省中医药局科研项目(No.20221261)。

摘　　要：紫草是中医外治法的常用中药,对皮肤疾患、创面感染和局部炎症效果显著,用于治疗水火烫伤、皮肤溃疡、湿疹、银屑病、白癜风和特应性皮炎等疾病。临床和市售紫草外用制剂以软膏剂、搽剂和栓剂等传统剂型为主。现代研究证明,微囊、纳米胶束、纳米纤维膜、纳米凝胶等新型外用纳米制剂可显著改善紫草药效物质的稳定性,提高局部药物的浓度和靶向性,并使其具有良好的体外释药性能。本文对紫草外用传统制剂的品种及应用情况和紫草新型外用纳米制剂的研究进展进行了综述,以期为紫草外用制剂的应用与开发提供参考。Arnebiae Radix is used widely in TCM external treatment.It has obvious curative effect on skin diseases,wound infection and local inflammation,and is used to treat water and fire burns,skin ulcers,eczema,psoriasis,vitiligo and atopic dermatitis,etc.The clinical and commercial preparations mainly include ointment,liniment and suppository.Modern research has proved that microcapsules,nano-micelles,nanofiber membranes,nanogels and other novel nanoformulations can significantly improve the stability of drug-effective substances,improve local drug concentration and targeting,and perform sound drug release properties in vitro.This paper reviews the variety and application of Arnebiae Radix traditional preparations for external use and the research progress of novel nanoformulations of Arnebiae Radix,from which we prospect to provide some valuable references for the future application and development of Arnebiae Radix external preparations.

关 键 词：紫草 外用制剂 传统制剂 纳米制剂 

分 类 号：R944[医药卫生—药剂学] R283.6[医药卫生—药学]