不同分类妊娠期高血压疾病患者血清LRRFIP、SREBP-1c、 FGF23的变化及对妊娠结局的影响  

Changes of serum LRRFIP,SREBP-1c and FGF23 in different categories of hypertensivedisorders of pregnancy and their effects on pregnancy outcome

作　　者：王娇 申文文 刘阳 宋荟琴 WANG Jiao;SHEN Wenwen;LIU Yang;SONG Huiqin(Department of Clinical Laboratory,Tongchuan Mining Bureau Central Hospital,Tongchuan,Shaanxi 727000,China;Department of Obstetrics and Gynecology,Tongchuan Mining Bureau Central Hospital,Tongchuan,Shaanxi 727000,China)

机构地区：[1]陕西省铜川矿务局中心医院检验科,陕西铜川727000 [2]陕西省铜川矿务局中心医院妇产科,陕西铜川727000

出　　处：《检验医学与临床》2023年第15期2154-2157,2161,共5页Laboratory Medicine and Clinic

基　　金：陕西省卫生健康委员会科学技术基金项目(2018SF0232)。

摘　　要：目的 研究不同分类妊娠期高血压疾病(HDP)患者血清富亮氨酸重复序列相互作用蛋白(LRRFIP)、胆固醇调节元件结合蛋白-1c(SREBP-1c)、成纤维细胞生长因子23(FGF23)的变化及其对妊娠结局的影响。方法 选择铜川矿务局中心医院2019年1月至2022年1月收治的92例HDP患者,并按照HDP类型,将其分为妊娠期高血压组34例、子痫前期组31例和重度子痫前期组27例。另取同期该院健康孕妇30例作为对照组。比较各组血清LRRFIP、SREBP-1c、FGF23水平。按照妊娠结局,将HDP患者分为不良妊娠结局组和良好妊娠结局组,比较两组患者血清LRRFIP、SREBP-1c、FGF23水平。采用多因素Logistic回归分析HDP患者不良妊娠结局的影响因素。结果 对照组、妊娠期高血压组、子痫前期组及重度子痫前期组血清LRRFIP、SREBP-1c、FGF23水平比较,差异均有统计学意义(P<0.05)。妊娠期高血压组、子痫前期组及重度子痫前期组血清LRRFIP、SREBP-1c、FGF23水平高于对照组,子痫前期组及重度子痫前期组高于妊娠期高血压组,重度子痫前期组高于子痫前期组,差异均有统计学意义(P<0.05)。92例HDP患者中,良好妊娠结局组42例,不良妊娠结局组50例。良好妊娠结局组和不良妊娠结局组患者的HDP类型、收缩压、舒张压及LRRFIP、SREBP-1c、FGF23水平比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示:重度子痫前期、收缩压>100.45 mm Hg、舒张压>144.45 mm Hg、血清LRRFIP>8.31 ng/mL、SREBP-1c>9.61μg/L、FGF23>124.26 pg/mL均是HDP患者不良妊娠结局的危险因素(P<0.05),而孕周>36.38周是HDP患者不良妊娠结局的是保护因素(P<0.05)。结论 HDP患者血清LRRFIP、SREBP-1c、FGF23水平均异常升高,且随着上述3项指标水平的升高,患者不良妊娠结局发生风险增加。Objective To study the changes of serum leucine-rich repeat interaction protein(LRRFIP),sterol regulatory element-binding protein-1c(SREBP-1c),fibroblasts growth factor 23(FGF23)and their effects on pregnancy outcome in different categories of hypertensive disorders of pregnancy(HDP).Methods A total of 92 HDP patients who were admitted to the Tongchuan Mining Bureau Central Hospital from January 2019 to January 2022 were selected,and divided into gestational hypertension group(34 cases),preeclampsia group(31 cases)and severe preeclampsia group(27 cases)according to the differences of HDP types.Another 30 healthy pregnant women in the same period were taken as the control group.The levels of serum LRRFIP,SREBP-1c and FGF23 were compared among all groups.According to the difference of pregnancy outcome,all HDP patients were divided into adverse pregnancy outcome group and good pregnancy outcome group,the levels of serum LRRFIP,SREBP-1c and FGF23 were compared between the two groups.The influencing factors of adverse pregnancy outcome in HDP patients were determined by multivariate Logistic regression analysis.Results The levels of serum LRRFIP,SREBP-1c and FGF23 among the control group,gestational hypertension group,preeclampsia group and severe preeclampsia group had statistically significant differences(P<0.05).Serum levels of LRRFIP,SREBP-1c and FGF23 were higher in the gestational hypertension group,preeclampsia group and severe preeclampsia group than those in the control group,and higher in the preeclampsia group and severe preeclampsia group than in the gestational hypertension group,and higher in the severe preeclampsia group than in the preeclampsia group,with statistically significant differences(P<0.05).Among 92 HDP patients,42 cases were in good pregnancy outcome group and 50 cases were in adverse pregnancy outcome group.The levels of gestational week,HDP type,systolic blood pressure and diastolic blood pressure between the good pregnancy outcome group and the adverse pregnancy outcome group has statist

关 键 词：妊娠期高血压疾病 血清富亮氨酸重复序列相互作用蛋白 胆固醇调节元件结合蛋白-1c 成纤维细胞生长因子23 妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]