RDW对极低出生体质量儿败血症的诊断价值  

Predictive value of red blood cell distribution width for sepsis in very low birth weight infants

作　　者：郭彬芳[1] 王海燕[1] 王玉春 梁秀英[1] 张春燕[1] 许萍萍 GUO Binfang;WANG Haiyan;WANG Yuchun;LIANG Xiuying;ZHANG Chunyan;XU Pingping(Department of Neonatology,Cangzhou Central Hospital,Cangzhou,Hebei 061000,China)

机构地区：[1]河北省沧州市中心医院新生儿科,河北沧州061000

出　　处：《检验医学与临床》2023年第15期2214-2217,共4页Laboratory Medicine and Clinic

基　　金：2020年河北省沧州市科技计划项目(204106078)。

摘　　要：目的 探讨红细胞分布宽度(RDW)对极低出生体质量儿败血症的诊断价值。方法 回顾性收集2020年1月至2021年6月于沧州市中心医院新生儿重症监护病房收治的60例极低出生体质量儿。根据是否发生败血症分为败血症组(25例)和对照组(35例)。比较两组实验室检查结果。采用受试者工作特征(ROC)曲线评价RDW、C反应蛋白(CRP)及降钙素原(PCT)对极低出生体质量儿败血症的诊断效能。采用多因素Logistic回归分析败极低出生体质量儿血症的影响因素。结果 败血症组的RDW、PCT、CRP水平高于对照组,血红蛋白水平低于对照,差异均有统计学意义(P<0.05)。RDW、CRP、PCT诊断极低出生体质量儿败血症的曲线下面积分别为0.781、0.721、0.686。RDW最佳截断值为17.29%,灵敏度、特异度分别为76.00%、77.14%。多因素Logistic回归分析发现,RDW、CRP、PCT是极低出生体质量儿败血症的独立影响因素(P<0.05)。结论 极低出生体质量儿患败血症时RDW明显升高,且RDW有助于提高对败血症的诊断效能。Objective To explore the potential clinical value of red blood cell distribution width(RDW)in the diagnosis of sepsis in very-low-birth-weight(VLBW)infants.Methods A retrospective case-control study was performed on 60 VLBW infants admitted to the NICU of Cangzhou Central Hospital from January 2020 to June 2021,and who were divided into the sepsis group(25 cases)and the control group(35 cases)according to whether sepsis occurs or not.Laboratory test results of both groups were compared.Receiver operating characteristic curve was adopted to evalate the diagnostic value of RDW,C-reactive protein(CRP)and procalcitonin(PCT)to sepsis in VLBW infants.Multivariate Logistic regression analysis was influencing factors of sepsis.Results The levels of RDW,PCT and CRP in the sepsis group were higher than those in the control group,while the level of hemoglobin was lower than that in the control group,and the differences had statistical significance(P<0.05).The area under the curve of RDW,CRP,and PCT in predicting neonatal sepsis was 0.781,0.721,and 0.686,respectively.When the optimal cut-off value of RDW was 17.29%,the sensitivity and specificity for predicting neonatal sepsis was 76.00%and 77.14%respectively.Multivariate Logistic regression analysis found that the serum RDW,CRP and PCT were the independent influencing factors for sepsis(P<0.05).Conclusion RDW is significantly higher in VLBW infants with sepsis,and RDW is helpful to improve the diagnostic efficacy of sepsis.

关 键 词：红细胞分布宽度 败血症 极低出生体质量儿 

分 类 号：R722.6[医药卫生—儿科]