紫云膏联合地奈德乳膏对慢性湿疹患者EASI评分及皮损面积的影响  

Effect of Ziyun ointment combined with desonidecream on EASI score andskin lesion area in patients with chronic eczema

作　　者：于男 陶阳[2] 朱忠[1] YU Nan;TAO Yang;ZHU Zhong(Department of Surgery,Nanchang Hongdu Hospital of Traditional Chinese Medicine/Acupuncture and Moxibustion Medical Clinical Research Center of Jiangxi Province/Nanchang Mayor′s Key Laboratory of Snake Moxibustion Effect Mechanism and Governor Vessel Specificit,Nanchang,Jiangxi 330000,China;Department of Dermatology,Nanchang Hongdu Hospital of Traditional Chinese Medicine/Acupuncture and Moxibustion Medical Clinical Research Center of Jiangxi Province/Nanchang Mayor′s Key Laboratory of Snake Moxibustion Effect Mechanism and Governor Vessel Specificit,Nanchang,Jiangxi 330000,China)

机构地区：[1]江西省南昌市洪都中医院/江西省针灸医学临床研究中心/南昌市长蛇灸效应机制和督脉特异性重点实验室外科,江西南昌330000 [2]江西省南昌市洪都中医院/江西省针灸医学临床研究中心/南昌市长蛇灸效应机制和督脉特异性重点实验室皮肤科,江西南昌330000

出　　处：《检验医学与临床》2023年第15期2247-2249,2255,共4页Laboratory Medicine and Clinic

摘　　要：目的 探讨紫云膏联合地奈德乳膏治疗慢性湿疹患者的效果。方法 采用随机数字表法将2021年1月至2022年6月南昌市洪都中医院收治的慢性湿疹患者80例分为对照组和观察组,每组40例。对照组采用地奈德乳膏治疗,观察组采用紫云膏联合地奈德乳膏治疗,均治疗4周。比较两组治疗效果、湿疹面积及严重程度指数(EASI)评分、皮损面积、不良反应及生活质量。结果 观察组治疗总有效率[95.00%(38/40)]高于对照组[77.50%(31/40)],差异均有统计学意义(P<0.05);治疗后,两组皮损面积及EASI评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率[10.00%(4/40)]与对照组[5.00%(2/40)]比较,差异无统计学意义(P>0.05);治疗后,两组WHO生存质量测定简表评分高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论 慢性湿疹患者采用紫云膏联合地奈德乳膏治疗效果满意,可有效降低EASI评分,缩小皮损面积,提高生活质量,且未增加不良反应,安全性好。Objective To explore the efficacy of Ziyun ointment combined with desonide cream in the treatment of patients with chronic eczema.Methods A total of 80 patients with chronic eczema admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from January 2021 to June 2022 were divided into control group and observation group using a random number table method,with 40 patients in each group.The control group was treated with desonide cream,while the observation group was treated with Ziyun cream combined with desonide cream,and patients in both group were treated for 4 weeks.The treatment effect,eczema area and severity index(EASI)score,lesion area,adverse effects and quality of life were compared between the two groups.Results The total effective rate of the observation group[95.00%(38/40)]was higher than that of the control group[77.50%(31/40)],with statistically significant difference(P<0.05).After treatment,the skin lesion area and EASI score of both groups were lower than before treatment,and the observation group was lower than the control group,with statistically significant differences(P<0.05).The difference of incidence of adverse reactions between the observation group[10.00%(4/40)]and the control group[5.00%(2/40)]had no statistical significance(P>0.05).After treatment,the WHOQOL-BREF scores of both groups were higher than before treatment,and the observation group was higher than the control group,with statistically significant differences(P<0.05).Conclusion Ziyun ointment combined with desonide cream in treating patients with chronic eczema has a satisfactory effect,which can effectively reduce the EASI score,reduce the area of skin lesions,improve quality of life,without increasing adverse reactions,and has good safety.

关 键 词：慢性湿疹 紫云膏 地奈德乳膏 湿疹面积及严重程度指数 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]