补肺汤治疗慢性阻塞性肺疾病急性加重期疗效及对患者Th1/Th2漂移的影响  

Effect of Bufei decoction on acute exacerbation of chronic obstructive pulmonary disease and its influence on Th1/Th2 drift

作　　者：王伟[1] 足巴措 张旭[1] WANG Wei;ZU Bacuo;ZHANG Xu(Chengdu First People’s Hospital,Chengdu 610041,China)

机构地区：[1]成都市第一人民医院成都市中西医结合医院,四川成都610041

出　　处：《陕西中医》2023年第8期1078-1081,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：四川省科技计划项目(2021YFS0272)。

摘　　要：目的:探究补肺汤佐治慢性阻塞性肺疾病急性加重期(AECOPD)疗效及对血清辅助T细胞1/辅助T细胞2(Th1/Th2)漂移的影响。方法:选取224例AECOPD肺气亏虚证患者,采用单双球法随机分为对照组和观察组,每组112例,对照组给予常规治疗,观察组在对照组基础上给予补肺汤治疗。治疗2周后,比较两组患者临床疗效、中医症候积分、痰液生化指标[痰液黏蛋白(MUC5AC)、中性粒细胞弹性蛋白酶(NE)、白细胞弹性蛋白酶抑制因子(elafin)]、血气指标[二氧化碳分压(PaCO_(2))、氧分压(PaO_(2))、pH]、Th1/Th2漂移及白介素-17(IL-17)水平。结果:治疗后,观察组总有效率高于对照组(P<0.05)。治疗后两组患者中医证候积分、MUC5AC、NE、PaCO_(2)、pH、IFN-γ、IL-4、IL-17水平较治疗前降低,观察组低于对照组(均P<0.05);治疗后两组elafin、PaO_(2)、IFN-γ/IL-4水平较治疗前升高,观察组高于对照组(均P<0.05)。结论:补肺汤治疗AECOPD肺气亏虚证患者疗效显著,可降低患者中医症候积分,改善患者痰液生化指标及血气指标,平衡免疫调节状态,缓解炎症反应。Objective:To explore the efficacy of Bufei decoction on acute exacerbation of chronic obstructive pulmonary disease and its influence on T helper cell type 1/T helper cell type 2(Th1/Th2)drift.Methods:224 patients with AECOPD lung qi deficiency syndrome were selected and randomly divided into control group and observation group by single-double ball method,112 cases in each group.The control group was given conventional treatment,and the observation group was additionally given Bufei decoction on the basis of the control group.After two weeks of treatment,the clinical efficacy,scores of TCM syndromes,sputum biochemical indicators[sputum mucin5AC(MUC5AC),neutrophil elastase(NE),leukocyte elastase inhibitor(elafin)],blood gas indicators[partial pressure of carbon dioxide(PaCO 2),partial pressure of oxygen(PaO 2),pH]and levels of serum Th1/Th2 drift and interleukin-17(IL-17)were compared between the two groups.Results:After treatment,the total effective rate in observation group was higher than that in control group(P<0.05).The scores of TCM syndromes and levels of MUC5AC,NE,PaCO 2,pH,IFN-γ,IL-4 and IL-17 in both groups were reduced compared with those before treatment,and above indicators in observation group were lower than those in control group(all P<0.05).The levels of elafin,PaO 2 and IFN-γ/IL-4 in the two groups were reduced compared to before treatment,and above indicators in observation group were higher than those in control group(all P<0.05).Conclusion:Bufei decoction adjuvant therapy has a significant effect on patients with AECOPD lung qi deficiency syndrome,and it can reduce the TCM syndromes scores,improve the sputum and blood gas indicators,balance the immune regulation status,and relieve the inflammatory response of patients.

关 键 词：慢性阻塞性肺疾病急性加重期 肺气亏虚证 补肺汤 TH1/TH2漂移 痰液生化指标 血气指标 

分 类 号：R563[医药卫生—呼吸系统]