培土生金方治疗肺部多重耐药菌感染疗效研究  

Study on the therapeutic effect of Peitu Shengjin prescription on pulmonary multidrug-resistant bacterial infection

作　　者：崔磊[1] 陈楠 颜琳 武加秀 仲洁 CUI Lei;CHEN Nan;YAN Lin;WU Jiaxiu;ZHONG Jie(Department of Intensive Care Medicine,Jining Hospital of Traditional Chinese Medicine,Jining 272004,China)

机构地区：[1]济宁市中医院重症医学科,山东济宁272004

出　　处：《陕西中医》2023年第8期1082-1085,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技项目(2021M081)。

摘　　要：目的:观察培土生金方治疗肺部多重耐药菌感染患者疗效及对白细胞(WBC)计数、降钙素原(PCT)、血乳酸(LAC)水平的影响。方法:选择肺部多重耐药菌感染患者60例,以随机数字表法分为两组,每组30例,对照组给予基础对症治疗,研究组在对照组基础上给予培土生金方治疗。治疗前、后检测两组患者WBC、PCT、LAC、动脉血氧分压(PaO_(2))、氧合指数(PaO_(2)/FiO_(2))水平和临床肺部感染评分(CPIS),记录患者细菌清除率、肺部炎症明显吸收时间、退热时间、机械通气时间,比较两组患者临床疗效、不良反应。结果:治疗后,研究组WBC、PCT、LAC含量低于对照组,PaO_(2)、PaO_(2)/FiO_(2)高于对照组(均P<0.05)。治疗后,研究组患者CPIS评分低于对照组(P<0.05)。研究组细菌清除率高于对照组,肺部炎症明显吸收时间、退热时间、机械通气时间较对照组短(均P<0.05)。研究组患者总有效率显著高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:培土生金方治疗肺部多重耐药菌感染患者,可抑制炎症级联反应,改善血气指标、氧代谢及肺功能,促进清除细菌,改善临床症状,提升临床疗效。Objective:To observe the therapeutic effect of Peitu Shengjin prescription in the treatment of pulmonary multidrug-resistant bacteria infection and its influence on the count of white blood cells(WBC),procalcitonin(PCT)and blood lactic acid(LAC).Methods:Sixty patients with pulmonary multidrug-resistant bacteria infection were selected and divided into two groups by random number table method,with 30 patients in each group.The control group was given basic symptomatic treatment,and the study group was given Peitu Shengjin prescription on the basis of the control group.Before and after treatment,WBC,PCT,LAC,arterial partial oxygen pressure(PaO 2)and oxygenation index(PaO 2/FiO 2)of the two groups were detected.Clinical pulmonary infection(CPIS)of the patients were evaluated.Bacterial clearance rate,obvious absorption time of pulmonary inflammation,fever reduction time and mechanical ventilation time of the patients were recorded.The clinical efficacy and adverse reactions were compared between the treatment group and the control group.Results:After treatment,the contents of WBC,PCT and LAC in the study group were lower than those in the control group,while the contents of PaO 2 and PaO 2/FiO 2 were higher than those in the control group(all P<0.05).After treatment,CPIS score in the study group was lower than that in the control group(P<0.05).The bacterial clearance rate of the study group was higher than that of the control group,and the obvious absorption time of pulmonary inflammation,fever reduction time and mechanical ventilation time were lower than those of the control group(all P<0.05).After treatment,the total effective rate of the study group was significantly higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the treatment of patients with pulmonary multidrug-resistant bacterial infection,Peitu Shengjin prescription can inhibit the inflammatory cascade,improve blood gas indexes,oxygen metaboli

关 键 词：肺部多重耐药菌感染 培土生金方 炎症级联反应 免疫功能 氧代谢 肺功能 

分 类 号：R259[医药卫生—中西医结合]