儿童的人博卡病毒感染研究进展  

Research progress of human bocavirus infection in children

作　　者：朱旭[1] 王丽杰[1] Zhu Xu;Wang Lijie(Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning,China)

机构地区：[1]中国医科大学附属盛京医院儿内科,辽宁沈阳110004

出　　处：《中华危重病急救医学》2023年第5期548-553,共6页Chinese Critical Care Medicine

基　　金：辽宁省科技重大专项(2020JH1/10300001)。

摘　　要：人博卡病毒是2005年首次于呼吸道样本中检出的新的病原体。人博卡病毒可感染不同年龄段的人群,主要易感人群为儿童,尤以6~24个月的婴幼儿多见。不同地区的流行季节因气候和地理位置的差异有所不同,好发于秋冬季。人博卡病毒1型与呼吸系统疾病密切相关,也可能导致威胁生命的重症,且症状的严重程度与病毒载量呈正相关。人博卡病毒1型常与其他病毒混合感染,可抑制干扰素分泌通路,影响宿主的免疫功能。目前人博卡病毒2~4型的致病性仍不明确,可能与胃肠疾病有关。诊断人博卡病毒急性感染单纯以聚合酶链反应检出DNA为依据并不可靠,应与mRNA、特异性抗原检测等多种方法联合应用,以提高诊断的准确性。目前对于人博卡病毒的认识仍然不足,尚需进一步研究。Human bocavirus is a novel pathogen first detected in respiratory tract samples in 2005.People of different ages can be infected by human bocavirus.Children are the susceptible population,especially the infants aged from 6-24 months old.The epidemic season varies in different regions due to the differences in climate and geographical location,and it mainly occurs in autumn and winter.It's demonstrated that human bocavirus-1 is closely related to respiratory system diseases and even causes life-threatening critical illness.Also,the severity of symptom is positively correlated with viral load.Co-infections between human bocavirus-1 and other viruses often present high frequency occurrence.Human bocavirus-1 interferes immune function of host by inhibiting interferon secrete pathway.Currently,it remains limited knowledge and understanding of the roles of human bocavirus 2-4 in diseases,but the gastrointestinal diseases should be paid more attention.Detection of human bocavirus DNA by traditional polymerase chain reaction(PCR)assay shouldn't be regarded as conclusive diagnostic basis.Instead,combined with mRNA and specific antigen detection,it is beneficial to improve the accuracy of diagnosis.Till now,the knowledge of human bocavirus remains poorly studied,which is deserved to further progress.

关 键 词：人博卡病毒 儿童 混合感染 致病性 

分 类 号：R725.1[医药卫生—儿科]