体外心肺复苏联合治疗性低温对脑保护作用的研究进展  

Research progress of extracorporeal cardiopulmonary resuscitation combined with therapeutic hypothermia on brain protection

作　　者：姚敏 翟科蓉 李鸣明[1] 李勇男[2,3] 葛朝明[1] Yao Min;Zhai Kerong;Li Mingming;Li Yongnan;Ge Zhaoming(Department of Neurology,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China;Department of Cardiac Surgery,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China;Extracorporeal Life Support Laboratory,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第二医院神经内科,甘肃兰州730030 [2]兰州大学第二医院心脏外科,甘肃兰州730030 [3]兰州大学第二医院体外生命支持实验室,甘肃兰州730030

出　　处：《中华危重病急救医学》2023年第5期554-557,共4页Chinese Critical Care Medicine

基　　金：甘肃省科技计划项目(20JR10FA663,20JR10RA760);甘肃省自然科学基金(22JR11RA050)。

摘　　要：相对于传统心肺复苏(CCRP),体外心肺复苏(ECPR)能够提高心搏骤停患者的生存率,并降低再灌注损伤,但仍难以避免发生继发性脑损伤的风险。低温管理对ECPR患者具有较好的神经保护潜能,可最大程度减少脑损伤。然而,与CCRP不同,ECPR没有明确的预后指标,ECPR联合低温管理相关的治疗措施与患者神经系统预后之间的关系尚未明确。本文就ECPR联合不同低温治疗措施对脑保护作用的研究进行综述,以期为ECPR患者神经系统损伤的预防和治疗提供参考依据。Compared with conventional cardiopulmonary resuscitation(CCPR),extracorporeal cardiopulmonary resuscitation(ECPR)can improve the survival rate of patients with cardiac arrest,and reduce the risk of reperfusion injury.However,it is still difficult to avoid the risk of secondary brain damage.Low temperature management has good neuroprotective potential for ECPR patients,which minimizes brain damage.However,unlike CCPR,ECPR has no clear prognostic indicator.The relationship between ECPR combined with hypothermia management-related treatment measure and neurological prognosis is not clear.This article reviews the effect of ECPR combined with different therapeutic hypothermia on brain protection and provides a reference for the prevention and treatment of neurological injury in patients with ECPR.

关 键 词：体外心肺复苏 治疗性低温管理 心搏骤停 脑保护 

分 类 号：R654.1[医药卫生—外科学]