High-purity Mg and Mg-1Ca alloys:Comparative assessment of the merits regarding degradation,osteogenesis,and biosafety for orthopedic applications  

作　　者：Baiyan Sui Hua Lu Xin Liu Jiao Sun 

机构地区：[1]Department of Dental Materials,Shanghai Biomaterials Research and Testing Center,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China

出　　处：《Journal of Materials Science & Technology》2023年第9期58-66,共9页材料科学技术（英文版）

基　　金：the Science and Technology Commission of Shanghai Municipality(18DZ2201500,19DZ2203900);Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212400);Research Disci-pline Fund(KQXJXK2021)from Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,and College of Stomatology,Shanghai Jiao Tong University.

摘　　要：High-purity magnesium(HP Mg)and Mg-1Ca,as representations of Mg-matrix implants produced by purifying and alloying,are employed in biomedical applications primarily because of their bioactivity and degradability.The superiority of both degradation properties,the match between degradation and osteo-genesis in vivo,and biosafety are critical problems that will decide future purifying or alloying to construct Mg-based implants and promote clinical translation.The present study investigated the benefits and limitations of degradation behavior and biosafety of HP Mg and Mg-1Ca according to the electro-chemical experiment,hydrogen evolution test,immersion test,and in vivo bone implantation assay.The results indicated that due to its Mg 2 Ca phase,Mg-1Ca exhibited a considerably higher corrosion current density and hydrogen production than HP Mg in vitro.Furthermore,HP Mg and Mg-1Ca display a favorable match between their degradation and the surrounding osteogenesis,resulting in no significant variation in degradation in vivo during 26 weeks.Additionally,the implantation and degradation of HP Mg and Mg-1Ca do not result in major organ dysfunction or pathological abnormalities.This work is expected to lay the foundation for future clinical translation of Mg and Mg alloy orthopedic implants.

关 键 词：High-purity magnesium Mg-1Ca Microstructure Degradation in vitro and vivo BIOSAFETY 

分 类 号：TG146.13[一般工业技术—材料科学与工程] R318.08[金属学及工艺—金属材料]