In vitro and in vivo evaluation of micro-alloyed magnesium for potential application in alveolar bone fixation screws  

作　　者：Hongyan Tang Qing Li Min Li Xuenan Gu Chengkung Cheng Yubo Fan 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China [2]Center of Digital Dentistry,Peking University School and Hospital of Stomatology,Beijing 100081,China [3]National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing 100081,China [4]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China

出　　处：《Journal of Materials Science & Technology》2023年第13期62-69,共8页材料科学技术（英文版）

基　　金：supported by the National Key R&D,Program of China (No.2018YFC1106600);the National Natural Science Foundation of China (Nos.52071008 and U20A20390);Beijing Natural Science Foundation (No.2192027).

摘　　要：Alveolar bone augmentation with fixation screws has difficulties such as non-degradable materials that could lead to secondary surgery and insufficient osseointegration due to the subgingival environment in dental practice.With degradability and a high degree of osteogenesis,Mg alloy is a successful biodegrad-able material for orthopedic applications,and its application in dentistry has made certain progress.How-ever,considering the unique subgingival healing properties of oral implants,there is still a gap between the desired material properties for clinical applications and available materials.Indeed,studies on the use of Mg-based fixation screws for dentistry applications are still rare.In this study,we reported a magnesium alloy with low combined addition of strontium and lanthanum.The mechanical properties,degradation behavior,osteogenesis,and gingival compatibility were systematically investigated for assess-ing its potential application in alveolar bone fixation screws.With the alloying element content restricted to 0.3 wt.%,Mg-Sr-La alloy still exhibited good mechanical properties,with yield tensile and compressive strength twice higher than those of pure Mg.The in vitro degradation rate of this alloy was 0.10 mm y-1,which was slightly slower than high-purity Mg.The indirect and direct cell assay confirmed the elevated osteoblastic differentiation of MC3T3-E1 and migration of HGF-1 cells.Moreover,Mg-Sr-La alloy demon-strated a relatively slow degradation in the maxillary bone of Beagles.A remarkable promotion of the bone-implant contacts and significantly decreased fibrous encapsulation was observed in the subgingival environment,implying superior osseointegration of the experimental alloy than the titanium control.The empirical findings here reveal the great potential of Mg-Sr-La alloy for the application in alveolar bone fixation devices.

关 键 词：Magnesium alloys Alveolar ridge augmentation Fixation screws OSSEOINTEGRATION 

分 类 号：TG174.4[金属学及工艺—金属表面处理]