氨酰tRNA合成酶非经典作用的研究进展  

Research Progress on Noncanonical Function of Aminoacyl-tRNA Synthetase

作　　者：王耀锋 宋自芳 Wang Yaofeng;Song Zifang(Hepatobiliary Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院肝胆外科,武汉430022

出　　处：《华中科技大学学报（医学版）》2023年第4期564-568,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81974040,No.82270412)。

摘　　要：氨酰tRNA合成酶(ARS)是一类在进化上高度保守且在生物体内广泛表达的必须酶,能将特定的氨基酸连接到同源tRNA,确保遗传信息的正确稳定传递。多种ARS通过蛋白质相互作用形成多tRNA合成酶复合物(MSC)。除了经典的催化合成作用,ARS还参与调控多种生物过程,如细胞凋亡、自噬、细胞衰老、血管生成等。为了更深入了解ARS的功能,该文对ARS的非经典作用进行综述。Aminoacyl-tRNA synthases(ARS)are a class of essential enzymes that are highly conserved in evolution and widely expressed in organisms.They can connect specific amino acids to homologous tRNAs to ensure the correct and stable transmission of genetic information.A variety of ARSs form multi-tRNA synthetase complex(MSC)through protein interac-tion.In addition to classical catalytic synthesis,ARS regulates various biological processes,such as apoptosis,autophagy,cell se-nescence,and angiogenesis.In order to better understand the function of ARS,this paper reviews the noncanonical effects of ARS.

关 键 词：氨酰TRNA合成酶 细胞凋亡 细胞自噬 细胞衰老 

分 类 号：R329.26[医药卫生—人体解剖和组织胚胎学]