中国不孕症患者治疗动因及阻因的调查研究  

Investigation on the treatment motivations and barriers of infertility patients in China

作　　者：李嘉[1] 程章[2] Randy Polyanna Po 郑祖庚 Marie Markert 杨蕊[1] Li Jia;Cheng Zhang;Polyanna Po Randy;Zheng Zugeng;Marie Markert;Yang Rui(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China;Clinical Research Department,Peking University Sixth Hospital,Peking University Insitute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,China;Ferring Pharmaceuticals,Shanghai 200122,China;Ferring Pharmaceuticals,Copenhagen 2300,Denmark)

机构地区：[1]北京大学第三医院妇产科生殖医学中心、国家妇产疾病临床医学研究中心(北京大学第三医院),北京100191 [2]北京大学第六医院临床研究室、北京大学精神卫生研究所、国家卫生健康委员会精神卫生学重点实验室(北京大学)、国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083 [3]辉凌医药咨询(上海)有限公司,上海200122 [4]辉凌制药公司,哥本哈根2300

出　　处：《中华生殖与避孕杂志》2023年第7期729-734,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划课题(2021YFC2700605)。

摘　　要：目的旨在调查中国不孕症患者或伴侣在不孕治疗过程中的感受、情绪、寻求治疗的动因和阻因。方法2019年3月15日至5月17日期间在中国等9个国家开展一项针对不孕症患者和伴侣的在线横断面定量问卷调查,共纳入1944名受访者,其中257名中国受访者被纳入分析。本研究基于156例中国不孕症患者(患者组)和101例伴侣(伴侣组:不孕患者的伴侣)的调查问卷对内容进行分析,并按照纳入对象、性别、治疗结局不同采用韦尔奇检验和卡方检验进行组间比较。结果257名被调查者年龄为(32.9±5.5)岁,女性占比为49.8%(128/257)。治疗过程中,患者组心理健康受影响的占比[83.3%(130/156)]显著高于伴侣组[72.3%(73/101),P=0.034]。患者组治疗相关的最常见情绪、身体症状影响分别为挫败感[27.5%(19/69)]、焦虑[27.5%(19/69)]和失眠症[44.9%(31/69)],伴侣组分别为焦虑[44.4%(12/27)]和情绪不稳定[55.6%(15/27)]。患者组和伴侣组最常见的治疗动因均为伴侣彼此的大力支持[37.0%(34/92),51.1%(23/45),P=0.126]、认为花时间妊娠是值得的[33.7%(31/92),55.6%(25/45),P=0.017]。最常见的就诊阻因为担心生育治疗对新生儿有影响[30.4%(7/23)]与伴侣对生孩子的渴望不相同[21.7%(5/23)]治疗费用昂贵[21.7%(5/23)]不知如何找到合适的医生[21.7%(5/23)]。结论伴侣彼此的大力支持和值得投入时间治疗的信念是最常见治疗动因,担心生育治疗会对新生儿产生影响是最常见阻因。解决患者及其伴侣的心理健康具有重要意义。Objective To understand the feelings and emotions of Chinese infertile patients and their partners on their journey of infertility treatment,and to understand their motivations and obstacles in seeking treatment.Methods An online cross sectional questionnaire survey on infertility patients and partners of infertile patients was conducted in 9 countries from March to May 2019.A total of 1944 respondents participated in the study,in which 257 respondents from China were included in this analysis.The survey analyzed the perceptions and emotions of infertility patients(patient group)and partners(partner group:partner of infertile patients)on their journey of infertility treatment from their perspective.Based on the questionnaire on 156 Chinese infertility patients and 101 partners,this study analyzed and made a comparative analysis of the inter-group differences using Welch's test andχ2 test based on different groups,genders and treatment outcomes.Results The average age of 257 respondents in China was(32.9±5.5)years,and the female respondents accounted for 49.8%(128/257).The proportion of mental health impacts of treatment journey in the patient group was significantly higher than that in the partner group[83.3%(130/156)vs.72.3%(73/101),P=0.034].The most common emotional and physical symptoms associated with fertility treatment were frustration[27.5%(19/69)],anxiety[27.5%(19/69)]and lack of sleep[44.9%(31/69)]in the patient group,anxiety[44.4%(12/27)]and emotional fluctuation[55.6%(15/27)]in the partner group.The most common motivations for treatment in both patients and partners were the strong support of partner[37.0%(34/92)vs.51.1%(23/45),P=0.126]and the belief that the time investment would be worth it to conceive a child[33.7%(31/92)vs.55.6%(25/45),P=0.017].Of respondents,the most common treatment consultation barriers were concerns about effects of fertility treatment on the newborn[30.4%(7/23)],partners having different desires for pregnancy[21.7%(5/23)],the high treatment cost[21.7%(5/23)]and couples didn'

关 键 词：不孕症 感受 情绪 治疗动因 治疗阻因 

分 类 号：R711.6[医药卫生—妇产科学]