miRNAs在心肌纤维化中的研究进展  

Research of miRNAs in myocardial fibrosis

作　　者：黄莉莉[1] 李志强 胡光玲[1] 杨巧芳[1] HUANG Li-li;LI Zhi-qiang;HU Guang-ling;YANG Qiao-fang(Heart Center of Henan Provincial People's Hospital,Nursing Department of Huazhong Fuwai Hospital of Zhengzhou University,Zhengzhou Henan,450003,China;School of Public Health,Kunming Medical University,KunmingYunnan,650000,China;School of Life Sciences,Tsinghua University,Beijing,100084,China)

机构地区：[1]河南省人民医院心脏中心暨郑州大学华中阜外医院护理部,河南郑州450003 [2]昆明医科大学公共卫生学院,云南昆明650000 [3]清华大学生命科学学院,北京100084

出　　处：《职业与健康》2023年第12期1714-1718,共5页Occupation and Health

基　　金：河南省自然科学基金项目(SB201901100)。

摘　　要：心肌纤维化是心脏间质成纤维细胞的过度增殖和细胞外基质组分的沉积增加导致心肌僵硬和舒张功能障碍,最终导致心功能不全的心脏病理改变。近年发现miRNA参与心肌纤维化和抗纤维化作用。miRNA可通过调节成纤维细胞的增殖、凋亡等过程参与心肌纤维化的发病过程。本文对近年关于miRNA在心肌纤维化的研究现状进行综述,以期为相关研究提供参考。The myocardial fibrosis refers to the proliferation of cardiac interstitial fibroblasts and the increase of extracellular matrix components,which lead to myocardial stiffness and diastolic dysfunction,and ultimately lead to cardiac pathological changes of cardiac insufficiency.In recent years,miRNA has been found to play a role in myocardial fibrosis and anti-fibrosis.The miRNA can participate in the pathogenesis of myocardial fibrosis by regulating the proliferation and apoptosis of fibroblasts and other processes.The paper reviews the research progress and current status of miRNA in myocardial fibrosis in recent years,in order to provide reference for related studies.

关 键 词：MIRNAS 心肌纤维化 通路 潜在靶点 

分 类 号：R181.3[医药卫生—流行病学]