大分子诱导表面等离子体纳米粒子的手性组装  

Chiral assembly of surface plasmonic nanoparticles induced by macromolecules

作　　者：沈知力 王昭一 张宁宁[1,3] 杨扬 刘堃[1] Zhili Shen;Zhaoyi Wang;Ning-Ning Zhang;Yang Yang;Kun Liu(State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012,China;Department of Gastrointestinal Colorectal and Anal Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China;Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education,Institute of Immunology,The First Hospital,Jilin University,Changchun 130012,China)

机构地区：[1]吉林大学化学学院,超分子结构与材料国家重点实验室,长春130012 [2]吉林大学白求恩第三临床医学院,胃肠结直肠肛门外科,长春130033 [3]吉林大学第一医院,免疫科器官再造与移植教育部重点实验室,长春130012

出　　处：《中国科学：化学》2023年第7期1104-1112,共9页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21674042,22225203,21911530179)资助项目。

摘　　要：手性是生物体中普遍存在的重要性质,监测手性的改变可成为观察及了解生理过程和病理改变的有力工具.然而,生物分子由于手性信号弱,所处环境复杂等诸多因素,其手性难以被探测及分析.近年来,基于纳米粒子表面化学与超分子相互作用,本课题组发展了多种手性大分子诱导表面等离子体纳米粒子手性自组装的方法,将手性信号由紫外区转移至可见-近红外区,通过构筑长程有序的手性组装结构,大幅提升其光学各向异性因子,并开发了手性纳米材料在复杂生理环境中对淀粉样类疾病的手性检测和药物筛选的新方法.本文将基于本课题组工作,介绍手性大分子诱导非手性表面等离子体纳米粒子自组装的进展,并提出本领域目前存在的挑战及未来发展思路.Chirality is an important property and widely prevalent in biological systems.Sensing chirality changes of biologic structures could be a potential tool for observing and understanding the physiological state and pathological changes.However,because of the week optical chiral signals of biomolecules and complex biological environment,it is difficult to detect and interpret their chirality changes.Based on surface chemistry of nanoparticles and supramolecular interactions,our research team has developed a series of approaches for macromolecular-induced chiral assembly of surface plasmonic nanoparticles with strong chiral signals.The chiral signals have been transferred from ultraviolet to the visible-near infrared region.The chiral signals were significantly amplified by the formation of long-range-ordered nanohelices,which were used for the detection of chirality changes of amyloid fibrils under complex biological environments.Based on the work of our team,we introduced the recent progress in macromolecular-induced chiral assembly of surface plasmonic nanoparticles,and discussed the current challenges and future development perspectives in the field.

关 键 词：手性纳米结构 表面等离子体 各向异性因子 手性传递 手性放大 

分 类 号：TB383.1[一般工业技术—材料科学与工程] O641.3[理学—物理化学]