PVA基水凝胶及其生物医学应用  

PVA-based hydrogels and their biomedical applications

作　　者：施晶 安琪[1] 李广涛[2] Jing Shi;Qi An;Guangtao Li(School of Materials Science and Engineering,China University of Geosciences(Beijing),Beijing 100083,China;Department of Chemistry,Tsinghua University,Beijing 100084,China)

机构地区：[1]中国地质大学(北京)材料科学与工程学院,北京100083 [2]清华大学化学系,北京100084

出　　处：《中国科学：化学》2023年第7期1134-1146,共13页SCIENTIA SINICA Chimica

基　　金：国家优秀青年科学基金(编号:NSFC29122203)资助项目。

摘　　要：水凝胶具有良好的生物相容性、力学强度、亲水性以及与组织相似的结构,已经被广泛应用于组织工程,其在软骨修复领域已经作为一种领军材料,展现出良好的修复效果.近年来,聚乙烯醇(PVA)的宽温度响应范围、柔性、灵敏度被研究人员所重视,已被发现多种潜在且新颖的应用,如人体运动监测、软体机器人、电子皮肤等,使PVA水凝胶成为了柔性/可穿戴基材的理想候选材料.本文综述了PVA水凝胶结构特征以及制备方法,以及通过不同种类的掺杂,实现其在组织工程、药物输送以及传感领域应用的关键性能要求,最后讨论了PVA基水凝胶在未来所面临的发展前景与挑战.With the good biocompatibility,mechanical strength,hydrophilicity,and tissue-like structure,hydrogels have been widely used in tissue engineering,and their use in cartilage repair has been shown as a leading material with good repair results.In recent years,polyvinyl alcohol's(PVA's) wide temperature response range,flexibility,and sensitivity have been valued by researchers,resulting in the discovery of a variety of potential and novel applications such as human motion monitoring,soft body robotics,and electronic skins.This makes PVA hydrogels an ideal candidate for flexible/wearable substrates.This review summarises the structural characteristics and preparation of PVA hydrogels,the key performance requirements for tissue engineering,drug delivery,and sensing applications through different types of doping,and finally discusses the prospects and challenges for the development of PVA-based hydrogels.

关 键 词：PVA水凝胶 组织修复 药物释放 传感 

分 类 号：R318.08[医药卫生—生物医学工程]