Advances in cardiovascular-related biomarkers to predict diabetic peripheral neuropathy  

作　　者：Meng-Ke Cheng Yao-Yao Guo Xiao-Nan Kang Lu Zhang Dan Wang Hui-Hui Ren Gang Yuan 

机构地区：[1]Department of Endocrinology,Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430030,Hubei Province,China

出　　处：《World Journal of Diabetes》2023年第8期1226-1233,共8页世界糖尿病杂志（英文版）（电子版）

基　　金：National Natural Science Foundation of China,No.82100922.

摘　　要：Diabetic peripheral neuropathy(DPN)is a common chronic complication of diabetes mellitus.One of the most common types is distal symmetric polyneuropathy,which begins as bilateral symmetry pain and hyperesthesia and gradually progresses into hypoesthesia with nerve fibre disorder and is frequently accompanied by depression and anxiety.Notably,more than half of patients with DPN can be asymptomatic,which tends to delay early detection.Furthermore,the study of adverse outcomes showed that DPN is a prominent risk factor for foot ulceration,gangrene and nontraumatic amputation,which decreases quality of life.Thus,it is essential to develop convenient diagnostic biomarkers with high sensitivity for screening and early intervention.It has been reported that there may be common pathways for microvascular and macrovascular complications of diabetes.The pathogenesis of both disorders involves vascular endothelial dysfunction.Emerging evidence indicates that traditional and novel cardiovascularrelated biomarkers have the potential to characterize patients by subclinical disease status and improve risk prediction.Additionally,beyond traditional cardiovascular-related biomarkers,novel cardiovascular-related biomarkers have been linked to diabetes and its complications.In this review,we evaluate the association between major traditional and nontraditional car-diovascular-related biomarkers of DPN,such as cardiac troponin T,B-type natriuretic peptide,Creactive protein,myeloperoxidase,and homocysteine,and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN.

关 键 词：DIABETES Diabetic peripheral neuropathy CARDIOVASCULAR MICROANGIOPATHY Prediction Biomarkers 

分 类 号：R587.1[医药卫生—内分泌]