Risk and predictors of severity and mortality in patients with type 2 diabetes and COVID-19 in Dubai  

作　　者：Fatheya Alawadi Alaaeldin Bashier Azza Abdulaziz Bin Hussain Nada Al-Hashmi Fawzi Al Tayb Bachet Mohamed Mahmoud Aly Hassanein Marwan Abdelrahim Zidan Rania Soued Amar Hassan Khamis Debasmita Mukhopadhyay Fatima Abdul Aya Osama Fatima Sulaiman Muhammad Hamed Farooqi Riad Abdel Latif Bayoumi 

机构地区：[1]Department of Endocrinology,Dubai Academic Health Corporation,Dubai,United Arab Emirates [2]Department of Medical Education and Research,Dubai Academic Health Corporation,Dubai,United Arab Emirates [3]Department of Radiology,Mediclinic City Hospital,Dubai,United Arab Emirates [4]College of Medicine,Mohamed Bin Rashid University of Medicine and Health Sciences,Dubai,United Arab Emirates [5]Dubai Diabetes Center,Dubai Academic Health Corporation,Dubai,United Arab Emirates [6]Basic Medical Sciences,College of Medicine,Mohammed Bin Rashid University of Medicine and Health Sciences,Dubai,United Arab Emirates

出　　处：《World Journal of Diabetes》2023年第8期1259-1270,共12页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND Globally,patients with diabetes suffer from increased disease severity and mortality due to coronavirus disease 2019(COVID-19).Old age,high body mass index(BMI),comorbidities,and complications of diabetes are recognized as major risk factors for infection severity and mortality.AIM To investigate the risk and predictors of higher severity and mortality among inhospital patients with COVID-19 and type 2 diabetes(T2D)during the first wave of the pandemic in Dubai(March–September 2020).METHODS In this cross-sectional nested case-control study,a total of 1083 patients with COVID-19 were recruited.This study included 890 men and 193 women.Of these,427 had T2D and 656 were non-diabetic.The clinical,radiographic,and laboratory data of the patients with and without T2D were compared.Independent predictors of mortality in COVID-19 non-survivors were identified in patients with and without T2D.RESULTS T2D patients with COVID-19 were older and had higher BMI than those without T2D.They had higher rates of comorbidities such as hypertension,ischemic heart disease,heart failure,and more life-threatening complications.All laboratory parameters of disease severity were significantly higher than in those without T2D.Therefore,these patients had a longer hospital stay and a significantly higher mortality rate.They died from COVID-19 at a rate three times higher than patients without.Most laboratory and radiographic severity indices in non-survivors were high in patients with and without T2D.In the univariate analysis of the predictors of mortality among all COVID-19 non-survivors,significant associations were identified with old age,increased white blood cell count,lymphopenia,and elevated serum troponin levels.In multivariate analysis,only lymphopenia was identified as an independent predictor of mortality among T2D non-survivors.CONCLUSION Patients with COVID-19 and T2D were older with higher BMI,more comorbidities,higher disease severity indices,more severe proinflammatory state with cardiac involvement,and died f

关 键 词：Type 2 diabetes COVID-19 Risk factors MORTALITY United Arab Emirates 

分 类 号：R563.1[医药卫生—呼吸系统] R587.1[医药卫生—内科学]