New environmental factors related to diabetes risk in humans:Emerging bisphenols used in synthesis of plastics  

作　　者：Rafael Moreno-Gómez-Toledano María Delgado-Marín Alberto Cook-Calvete Claudia González-Cucharero Nunzio Alcharani Beatriz Jiménez-Guirado Ignacio Hernandez Rafael Ramirez-Carracedo Laura Tesoro Laura Botana Sandra Sánchez-Esteban Javier Diez-Mata Jose Luis Zamorano Ricardo J.Bosch Carlos Zaragoza Marta Saura 

机构地区：[1]Universidad de Alcalá,Department of Biological Systems/Physiology,Alcaláde Henares 28871,Spain [2]Cardiology Department,University Hospital Ramón y Cajal,Madrid 28034,Spain [3]Laboratory of Cardiovascular Pathophysiology,Joint Translational Research Unit,University Francisco de Vitoria School of Medicine,Madrid 28034,Spain [4]Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS,Madrid 28034,Spain

出　　处：《World Journal of Diabetes》2023年第8期1301-1313,共13页世界糖尿病杂志（英文版）（电子版）

基　　金：the“Margarita Salas”postdoctoral fellowship from the Universidad de Alcalá;and FPI fellowships from the Universidad de Alcalá.

摘　　要：BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st century.In recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the art.Subsequently,a meta-analysis was performed to unify the existing quantitative data.METHODS Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of results.Subsequently,three authors analyzed the set of articles.Finally,a meta-analysis was performed for each BP,using RevMan software.In addition,funnel plots were developed to study publication bias.RESULTS The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study paradigm.The qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and BPAF.Finally,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with BPS.CONCLUSION There is a need to apply the precautionary principle,regulating the use of new BPs.Therefore,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.

关 键 词：Bisphenol S Bisphenol F Bisphenol AF Diabetes mellitus Systematic review META-ANALYSIS 

分 类 号：R587.1[医药卫生—内分泌]