Recurrent ventricular arrhythmia due to aconite intoxication successfully treated with landiolol:A case report  

作　　者：Chiaki Matsuo Koji Yamamoto Hidetada Fukushima Daisuke Yajima Hiroyuki Inoue 

机构地区：[1]Department of Emergency and Critical Care Medicine,Nara Medical University,Kashihara City 634-8522,Nara,Japan [2]Department of Forensic Medicine,School of Medicine,International University of Health and Welfare,Narita City 286-8686,Chiba,Japan

出　　处：《World Journal of Clinical Cases》2023年第22期5303-5308,共6页世界临床病例杂志

摘　　要：BACKGROUND Ventricular arrhythmias,such as ventricular tachycardia and fibrillation,are the main causes of death in patients with aconite poisoning.CASE SUMMARY A 51-year-old man presented to our emergency department because he was vomiting after ingesting aconite root to attempt suicide.On arrival,the patient was hemodynamically unstable,and his electrocardiogram revealed polymorphic ventricular extrasystoles and non-sustained ventricular tachycardia.Amiodarone was immediately administered for ventricular arrhythmia.However,the patient remained unresponsive.We administered continuous intravenous landiolol as the ventricular arrhythmia worsened,gradually suppressing it.The patient returned to sinus rhythm 16 h after arriving at the hospital.Some aconitum alkaloids act on voltage-gated Na+-channels and induce ventricular or supraventricular tachyarrhythmias.Landiolol suppresses sympathetic nerve activity through its blocking effect,preventing arrhythmia.CONCLUSION Landiolol can be a therapeutic option for amiodarone-refractory ventricular arrhythmias caused by aconite intoxication.

关 键 词：ACONITE LANDIOLOL AMIODARONE Arrhythmia TOXICOLOGY Case report 

分 类 号：R541.7[医药卫生—心血管疾病]