苯二氮[艹卓]类药物检测提取技术的研究进展  

Research Progress on Detection and Extraction Technology of Benzodiazepines

作　　者：陈晓兵 李慧文[1] 戴欣成 周全 沙鸥 吴赟帆 王滋文 CHEN Xiaobing;LI Huiwen;DAI Xincheng;ZHOU Quan;SHA Ou;Wu Yunfan;WANG Ziwen(School of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,Jiangsu,China;The First People’s Hospital of Lianyungang,Lianyungang 222061,Jiangsu,China;School of Environmental and Chemical Engineering,Jiangsu Ocean University,Lianyungang 222005,Jiangsu,China)

机构地区：[1]江苏海洋大学药学院,江苏连云港222005 [2]连云港市第一人民医院,江苏连云港222061 [3]江苏海洋大学环境与化学工程学院,江苏连云港222005

出　　处：《中国药物滥用防治杂志》2023年第7期1120-1124,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：2022年江苏省大型科学仪器开放共享自主研究(编号:2022039);江苏省产学研合作项目(编号:BY2022285);连云港高新区科技计划项目(编号:ZD201925);2020年江苏海洋大学研究生教育教学改革立项课题(编号:YJG202005);研究生科研与实践创新计划项目(编号:KYCX2021-022,KYCX2022-33)。

摘　　要：苯二氮[艹卓]类药物(BZDs)属于第二代镇静催眠药,具有安全性高、疗效确切以及价格低廉的特点,因此在临床镇静镇痛中被广泛使用。尽管BZDs安全性较高,但滥用该类药物不仅会损害肝脏和肾脏,严重者甚至会出现成瘾性和戒断综合征。同时,具有致幻作用的BZDs也被用于麻醉抢劫、非法添加等犯罪活动中。因此,准确检测不同来源样品中BZDs的含量对临床研究和应用至关重要。本文对近年来苯二氮[艹卓]类药物的检测手段和样品前处理方法进行综述,以期为临床相关工作者检测该类药物提供一定的参考和借鉴。Benzenediazepines(BZDs)belong to the second generation of sedative hypnotics,which have the characteristics of high safety,exact efficacy and low price,so they are widely used in clinical sedation and analgesia.Although the safety of BZDs is high,the abuse of such drugs will not only damage the liver and kidneys,but even lead to addiction and withdrawal syndrome in severe cases.At the same time,BZDs with hallucinogenic effects are also used in criminal activities such as narcosis robbery and illegal addition.Therefore,it is very important for clinical research and application to accurately detect the content of BZDs in samples from different sources.In this paper,the detection methods and sample pretreatment methods of benzodiazepines in recent years were reviewed.It is expected to provide some reference for clinical workers to detect this kind of drugs.

关 键 词：苯二氮[艹卓]类药物 检测技术 前处理手段 分析进展 

分 类 号：R927.1[医药卫生—药学]