注射用美罗培南两步点滴法治疗老年重症肺炎的效果研究  

Clinical Effect of Two Step Drip Therapy with Meropenem for Injection in the Treatment of Severe Pneumonia in the Elderly and its Influence on Serum Inflammatory Factors

作　　者：高明谦 余景伟 GAO Mingqian;YU Jingwei(Department of Respiratory and Critical Care Medicine,Gucheng County People’s Hospital/Gucheng Hospital Affiliated to Hubei University of Arts and Sciences,Gucheng 441700,Hubei,China)

机构地区：[1]谷城县人民医院/湖北文理学院附属谷城医院呼吸与危重症医学科,湖北谷城441700

出　　处：《中国药物滥用防治杂志》2023年第7期1229-1232,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:观察注射用美罗培南两步点滴法对老年重症肺炎的治疗效果及对血清炎症因子的影响。方法:将2020年1月-2023年2月接收的86例老年重症肺炎患者按随机数字表法分为对照组(n=43)、试验组(n=43)。对照组实施注射用美罗培南常规输注,试验组实施注射用美罗培南两步点滴法,比较两组总体疗效,病情程度[急性生理与慢性健康评分系统(APACHEⅡ)、肺炎严重程度评分系统(PSI)]、血清炎症因子水平[白介素-6(IL-6)、超敏C反应蛋白(Hs-CRP)、降钙素原(PCT)]及不良反应。结果:治疗后,试验组总有效率为90.70%,高于对照组的72.09%(P<0.05);试验组APACHEⅡ评分、PSI评分低于对照组(P<0.05);试验组血清IL-6、Hs-CRP、PCT水平低于对照组(P<0.05);两组用药后不良反应发生率比较,差异无统计学意义(P>0.05)。结论:注射用美罗培南两步点滴法能提高老年重症肺炎治疗效果,促进病情改善,下调血清炎症因子水平,且未明显增加不良反应。Objective:To observe the therapeutic effect of two step infusion of meropenem for injection on severe pneumonia in the elderly and its influence on serum inflammatory factors.Methods:A total of 86 elderly patients with severe pneumonia received from January 2020 to February 2023 were randomly divided into control group(n=43)and experimental groupl(n=43)according to the random digital table method.The control group received routine infusion of meropenem for injection,while the experimental group received two step drip therapy of meropenem for injection.The overall efficacy,severity of disease[acute physiology and chronic health scoring system(APACHEⅡ),pneumonia severity scoring system(PSI)],serum inflammatory factor levels[interleukin-6(IL-6),high-sensitivity C-reactive protein(Hs-CRP),procalcitonin(PCT)]and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of experimental group was 90.70%,which was higher than 72.09% of control group(P<0.05).APACHEⅡscore and PSI score of experimental group were lower than those of control group(P<0.05).The levels of IL-6,Hs-CRP and PCT in experimental group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The two-step drip method of meropenem for injection can improve the therapeutic effect of severe pneumonia in the elderly,promote the improvement of the disease,down-regulate the level of serum inflammatory factors,and not significantly increase the adverse reactions.

关 键 词：重症肺炎 美罗培南 两步点滴法 炎症因子 

分 类 号：R563.1[医药卫生—呼吸系统]