Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target  

作　　者：Kai Wang 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2023年第8期1460-1460,共1页Sichuan Journal of Physiological Sciences

摘　　要：A mechanistic understanding of how microbial proteins affect the host could yield deeper insights into gut microbiota-host cross-talk.We developed an enzyme activity-screening platform to investigate how gut microbiota-derived enzymes might influence host physiology.We discovered that dipeptidyl peptidase 4(DPP4)is expressed by specific bacterial taxa of the microbiota.Microbial DPP4 was able to decrease the active glucagon like peptide-1(GLP-1)and disrupt glucose metabolism in mice with a leaky gut.Furthermore,the current drugs targeting human DPP4,including sitagliptin,had little effect on microbial DPP4.Using high-throughput screening,we identified daurisoline-d4(Dau-d4)as a selective microbial DPP4 inhibitor that improves glucose tolerance in diabetic mice.

关 键 词：DIABETIC metabolism DPP4 

分 类 号：R587.1[医药卫生—内分泌]