IGF-1在良性前列腺增生疾病中的研究进展  

The Research Progress of IGF-1 in Benign Prostatic Hyperplasia

作　　者：聂瑞丽[1] 吴丽娜[1] 秦晓松[1] NIE Ruili;WU Lina;QIN Xiaosong(Medical Laboratory Center of Shengjing Hospital of China Medical Unversity,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院检验科,辽宁沈阳110000

出　　处：《标记免疫分析与临床》2023年第5期872-875,892,共5页Labeled Immunoassays and Clinical Medicine

基　　金：国家重点研发计划(主动健康和老龄化科技应对重点专项,老年前列腺增生的综合防控技术研究与精准风险评估和个体化防治措施应用示范)(编号:2021YFC2009300);国家重点研发计划(老年前列腺增生专业防控联盟与临床数据和样本资源库的构建)(编号:2021YFC2009301)。

摘　　要：良性前列腺增生(benign prostatic hyperplasia,BPH)是引起中老年男性排尿障碍最为常见的一种良性疾病。主要表现为组织学上的前列腺间质和腺体成分的增生、解剖学上的前列腺增大、尿流动力学上的膀胱出口梗阻。BPH在我国具有发病率高、人群分布广等特点。目前为止,BPH的发病机制尚不明确。胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)在细胞的增殖、分化和凋亡的整个过程中发挥重要作用。本文对IGF-1的生理特点进行概述,回顾了IGF-1在BPH的流行病学的情况,以及其参与的信号通路在BPH中的作用,从而为BPH的预防和治疗提供理论基础。Benign prostatic hyperplasia(BPH)is one of the most common benign diseases causing urinary dysfunction in middle-aged and elderly men populations.The main manifestations were histological hyperplasia of the prostatic interstitial and glandular components,anatomic enlargement of the prostate,and urinary flow mechanical obstruction of the bladder outlet.BPH has a high incidence and wide distribution in our country.So far,the pathogenesis of BPH is not clearly studied.Insulin-like growth factor-1(IGF-1)plays an important role in the whole process of cell proliferation,differentiation and apoptosis.In this article,we summarized the physiological characteristics of IGF-1.Specifically,the epidemiological status of IGF-1 in BPH and the role of IGF-1 signaling pathway in BPH were reviewed,so as to provide a theoretical basis for the prevention and treatment of BPH.

关 键 词：良性前列腺增生 胰岛素样生长因子-1 标志物 治疗 

分 类 号：R697.12[医药卫生—泌尿科学]