中医综合治疗121例中晚期非小细胞肺癌的生存分析  

Survival analysis of 121 cases of advanced non-small cell lung cancer tre ated by TCM

作　　者：沈楚然 高静东[1] 张子文[2] 陈雪风 刘敏[1] 张蕾[1] SHEN Churan;GAO Jingdong;ZHANG Ziwen;CHEN Xue feng;LIU Min;ZHANG Lei(Suzhou Hospital of Traditional Chinese Medicine,Nanjing University o f Chinese Medicine,Suzhou Jiangsu 215000;The Second People's Hospital of Changshu City,Changshu Jiangsu 215500)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215000 [2]常熟市第二人民医院,江苏常熟215500

出　　处：《当代医药论丛》2023年第15期155-157,共3页

基　　金：江苏省研究生科研与实践创新计划项目:参一胶囊联合免疫治疗晚期非小细胞肺癌的临床研究(SJCX21_0757);苏州市姑苏卫生人才计划培养项目:β3GnT8在四逆汤多糖复方调控原发性肝癌细胞糖基化及侵袭转移中的作用及分子机制,项目编号:GSWS2020081;苏州市卫生计生委科技项目:中医综合治疗中晚期非小细胞肺癌的诊疗技术(LCZX201916)。

摘　　要：目的:探讨中医综合治疗与中晚期非小细胞肺癌(NSCLC)患者生存期之间的相关性。方法:回顾性研究住院治疗的121例中晚期NSCLC患者的临床资料,根据治疗方式的差异将其分为西医治疗组、中医综合治疗组,观察两组治疗前后中医症状积分、KPS评分的变化,并绘制Kaplan-Meier生存曲线,采用Log-rank检验比较不同亚组患者的生存情况,通过多因素Cox回归分析模型分析各因素对患者生存期的影响。结果:经治疗,中医综合治疗组的中位生存时间(MST)、中医症状积分、Karnofsky功能状态(KPS)评分均优于西医治疗组(P<0.05)。单因素分析显示,中医综合治疗、年龄、肿瘤脑转移、肿瘤肝转移、初始KPS评分为影响中晚期NSCLC患者生存期的因素(P<0.05)。多因素Cox回归分析发现,年龄、病理类型为非腺癌、肿瘤脑转移、肿瘤肝转移为中晚期NSCLC患者死亡终点事件的独立危险因素,中医综合治疗为中晚期NSCLC患者预后的独立保护因素。结论:中医综合治疗对中晚期NSCLC患者的生存期有较明显的保护作用,值得推广。Objective:To investigate the correlation between TCM comprehensive treatment and survival of patients with advanced non-small cell lung cancer(NSCLC).How:A retrospective study was conducted on the clinical data of 121 patients with advanced NSCLC who were hospitalized and divided into Western medicine treatment group and Chinese medicine comprehensive treatment group according to the differences in treatment methods.The changes of Chinese medicine symptom score and KPS score before and after treatment of the two groups were observed,and Kaplan-Meier survival curve was drawn.Log-rank test was used to compare the survival of patients in different subgroups,and the influence of each factor on the survival of patients was analyzed by multi-factor Cox regression analysis model.Results:After treatment,the median survival time(MST),TCM symptom score and Karnofsky functional status(KPS)score of TCM integrated treatment group were better than those of Western treatment group(P<0.05).Univariate analysis showed that TCM combined treatment,age,tumor brain metastasis,tumor liver metastasis and initial KPS score were the factors affecting the survival of patients with middle and advanced NSCLC(P<0.05).Multivariate Cox regression analysis showed that age,pathological type of non-adenocarcinoma,tumor brain metastases and tumor liver metastases were independent risk factors for death endpoint events in patients with advanced NSCLC,and TCM combined treatment was independent protective factors for prognosis in patients with advanced NSCLC.Conclusion:TCM comprehensive treatment has a significant protective effect on the survival of patients with advanced NSCLC,and it is worth promoting.

关 键 词：中晚期非小细胞肺癌 中医综合治疗 生存分析 

分 类 号：R273[医药卫生—中西医结合]