银离子敷料对皮肤擦伤患儿创面愈合及机体炎症因子水平的影响  

Effect of silver ion dressing on wound healing and inflammatory factors levels of the body in children with skin abrasion

作　　者：王武愉 惠慧 郑佳敏 WANG Wuyu;HUI Hui;ZHENG Jiamin(Group of Orthopedics-Burn Plastic Surgery,Children′s Hospital Affiliated to Jiangnan University,Wuxi 214000,Jiangsu,China)

机构地区：[1]江南大学附属儿童医院(无锡市儿童医院)骨科-烧伤整形组,江苏省无锡市214000

出　　处：《广西医学》2023年第11期1301-1304,共4页Guangxi Medical Journal

基　　金：江苏省无锡市儿童医院科研项目(BKB201710)。

摘　　要：目的探讨银离子敷料对皮肤擦伤患儿创面愈合及机体炎症因子水平的影响。方法将136例皮肤擦伤患儿随机分为观察组和对照组,每组68例。给予观察组银离子敷料换药,给予对照组传统干纱布换药。比较两组的疗效、临床指标(创面愈合所需时间、换药次数、创面感染率、水泡发生率),治疗前后血清炎症因子[白细胞介素(IL)-6、IL-10、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)]水平及疼痛视觉模拟量表(VAS)评分,以及治疗后不同时间点的温哥华瘢痕量表(VSS)评分。结果与对照组比较,观察组的愈合率更高,创面愈合所需时间、换药次数更少,创面感染率及水泡发生率更低(均P<0.05)。治疗后,两组血清IL-6、CRP、TNF-α水平及疼痛VAS评分均低于治疗前,IL-10均高于治疗前,且观察组上述指标改善均优于对照组(均P<0.05)。治疗后7 d、11 d,两组VSS评分均较治疗后3 d降低,且观察组VSS评分均低于对照组(均P<0.05)。结论采用银离子敷料治疗小儿皮肤擦伤,可有效改善机体炎症因子水平,降低感染发生率,从而促进创面愈合,缓解瘢痕形成,效果优于常规干纱布换药。Objective To explore the effect of silver ion dressing on wound healing and inflammatory factors levels of the body in children with skin abrasion.Methods A total of 136 children with skin abrasion were randomly assigned to observation group or control group,with 68 cases in each group.The observation group received dressing change with silver ion,and the control group received dressing change with traditional dry gauze.The efficacy,clinical indices with respect to duration for wound healing,frequency of dressing change,wound infection rate,and blister incidence rate,and pre-and post-treatment serum inflammatory factors levels in terms of interleukin(IL)-6,IL-10,C reactive protein(CRP),and tumor necrosis factorα(TNF-α),Visual Analogue Scale(VAS)score for pain,as well as post-treatment Vancouver Scar Scale(VSS)score at different time points were compared between the two groups.Results As compared with the control group,the observation group exhibited a higher healing rate,and less duration for wound healing,less frequency of dressing change,and lower wound infection rate and blister incidence rate(all P<0.05).After treatment,both groups interpreted lower levels of serum IL-6,CRP,and TNF-α,and a lower VAS score for pain as compared with before treatment,whereas a higher level of serum IL-10 as compared with before treatment;moreover,the observation group yielded superior improvements of indices as above as compared with the control group(all P<0.05).After 7 and 11 days of treatment,the VSS score in both groups was lower as compared with 3 days after treatment,and the observation group presented a lower VSS score as compared with the control group(all P<0.05).Conclusion Employing silver ion dressing for treating children with skin abrasion can effectively ameliorate inflammatory factors levels of the body,and decrease the incidence rate of infection,so as to promote wound healing,relieve scar formation,exerting a superior effect to dressing change with traditional dry gauze.

关 键 词：皮肤擦伤 银离子敷料 换药 炎症因子 创面愈合 儿童 

分 类 号：R641[医药卫生—外科学]