MTHFR C677T基因多态性与H型高血压及其靶器官损害的相关研究进展  

Research progress on the correlation of MTHFR C677T gene polymorphism with H-type hypertension and its target organ damage

作　　者：郑巧玲 张驰 李军[1] ZHENG Qiao-ling;ZHANG Chi;LI Jun

机构地区：[1]承德医学院附属医院全科医疗科,河北承德067000 [2]承德医学院附属医院神经内科,河北承德067000

出　　处：《中国疗养医学》2023年第9期958-962,共5页Chinese Journal of Convalescent Medicine

基　　金：2022年度河北省医学科学研究课题计划(20220008)。

摘　　要：H型高血压患者占原发性高血压的75%,同型半胱氨酸(Hcy)作为一种含巯基的毒性氨基酸,在H型高血压人群中,高Hcy与高血压协同对心脑肾等靶器官造成损害,严重危害患者的生命健康和生活质量,故关注H型高血压的病因,对其进行提前预防和治疗至关重要。既往对H型高血压病因的研究更多关注于吸烟、高龄、饮食等环境因素。近年来,随着科研技术水平的提高,亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因尤其是C677T位点成为人们研究的热点。MTHFR作为Hcy代谢的关键酶,其基因突变与H型高血压的发病及靶器官的损害有着密不可分的关系。但由于基因的分布具有地区与种族的差异性,故其同一疾病在不同地区与种族的相关性研究结果可能不一致。现将MTHFR C677T基因多态性与H型高血压及其靶器官损害的相关性研究进展进行综述。H-type hypertension accounts for 75%of patients with essential hypertension.Homocysteine(Hcy)is a toxic amino acid containing sulfhydryl groups.High-level Hcy and hypertension synergistically cause damages to target organs like the heart,brain and kidneys,which severely impairs the health and quality of life.Therefore,it is vital to focus on the causes of H-type hypertension and to prevent and treat it in advance.Previous studies on the etiology of H-type hypertension have focused more on environmental factors like smoking,advanced age and diet.In recent years,the methylenetetrahydrofolate reductase(MTHFR)gene,especially the C677T locus,has become a hot research topic.As a key enzyme in Hcy metabolism,mutations in the MTHFR gene are inextricably linked to the development of H-type hypertension and damage to target organs.However,the correlation between mutations in the MTHFR gene and H-type hypertension in different regions and races is controversial due to the varied genetic distribution.This article aims to review the relevant research about the correlation of MTHFR C677T gene polymorphism with H-type hypertension and its target organ damage.

关 键 词：亚甲基四氢叶酸还原酶C677T基因 H型高血压 靶器官损害 

分 类 号：R544.1[医药卫生—心血管疾病]