抑郁障碍与中医体质相关性研究的系统评价和Meta分析  

Correlation Between TCM Constitution and Depressive Disorder:A Systematic Review and Meta-analysis

作　　者：胡文悦 韩振蕴[1] 王振亦 常泽 林景峰 马华萍 王育纯 HU Wenyue;HAN Zhenyun;WANG Zhenyi;CHANG Ze;LIN Jingfeng;MA Huaping;WANG Yuchun(Shenzhen Hospital of Beijing University of Chinese Medicine,Shenzhen 518100,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学深圳医院〔龙岗〕,深圳518100 [2]北京中医药大学东方医院,北京100078

出　　处：《世界中医药》2023年第14期1986-1994,共9页World Chinese Medicine

基　　金：国家重点研发计划项目(2019YFC1710103);深圳市医疗卫生三名工程项目(SZZYSM202105010)。

摘　　要：目的:系统评价抑郁障碍中医9种体质分布情况,初步明确抑郁患者中医体质分布规律,为从体质角度防治抑郁提供一定参考。方法:计算机检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库、PubMed,纳入抑郁中医体质类型相关文献,应用R软件进行单个率的Meta分析,根据是否患病及程度分亚组应用RevMan 5.3软件分别进行Meta分析,结果以分布率、比值比(OR)及其95%置信区间表达效应值。结果:共纳入14项研究,10 484例样本。抑郁人群气郁体质占比27%,气虚体质占比26%,阈下抑郁人群气郁体质占比38%,气虚体质占比20%,组间比较气郁质、气虚质抑郁较非抑郁占比高有统计学意义,平和质非抑郁较抑郁占比高有统计学意义,气虚质在中重度抑郁较阈下抑郁分布比例高差异有统计学意义。文献质量评价总体偏低,存在偏倚风险。结论:气郁质、气虚质是抑郁人群主要体质类型,其与无抑郁人群存在明显差异,气虚质在中重度抑郁人群中更为多见,这可能成为调体质防治抑郁的切入点。Objective:To systematically evaluate the distribution of nine traditional Chinese medicine(TCM)constitutions in patients with depression and to preliminarily clarify the distribution patterns of TCM constitutions in patients with depression,providing a reference for the prevention and treatment of depression from the perspective of constitutions.Methods:China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),Chinese Citation Database(CCD),and PubMed were searched for relevant literature on TCM constitutions in depression.R software was used for Meta-analysis of single rates,and RevMan 5.3 software was used to conduct separate Meta-analyses for subgroups based on disease status and severity.The results were expressed as distribution rates,odds ratios(OR),and their 95%confidence intervals.Results:Fourteen studies involving 10484 participants were included.Among the depression population,the prevalence of the qi stagnation constitution was 27%,and the prevalence of the qi deficiency constitution was 26%.In the subpopulation with subthreshold depression,the prevalence of the qi stagnation constitution was 38%,and the prevalence of the qi deficiency constitution was 20%.The inter-group comparison revealed the prevalence of the qi stagnation and qi deficiency constitutions was significantly higher in the depression group than in the non-depression group.Conversely,the prevalence of the balanced constitution was significantly higher in the non-depression group than in the depression group.The prevalence of the qi deficiency constitution was significantly higher in the moderate-to-severe depression group than in the subthreshold depression group,showing a statistically significant difference.The overall quality of the literature was low,and there was a risk of bias.Conclusion:The qi stagnation and qi deficiency constitutions are the main constitution types in the depression population,showing significant differences compared with the non-depression population.The qi deficiency constitution i

关 键 词：中医体质 抑郁障碍 阈下抑郁 混合性焦虑抑郁障碍 系统评价 META分析 

分 类 号：R277.7[医药卫生—中医学]