血液学参数在系统性红斑狼疮中的应用价值  

Application value of hematological parameters in systemic lupus erythematosus

作　　者：杨志革[1] 周颖沛 梁盛华 劳小霞[1] YANG Zhige;ZHOU Yingpei;LIANG Shenghua;LAO Xiaoxia(Laboratory Department,Minzu Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001,China)

机构地区：[1]广西壮族自治区民族医院检验科,广西南宁530001

出　　处：《临床医学研究与实践》2023年第22期11-14,20,共5页Clinical Research and Practice

基　　金：广西崇左市科技计划项目(崇科攻2019013)。

摘　　要：目的探讨血液学参数在系统性红斑狼疮(SLE)发生发展中的临床应用价值。方法选取2012年1月至2020年12月在我院确诊的278例SLE患者作为SLE组,选取同期在我院体检的278名健康体检者作为对照组,筛选出与SLE相关的特征血液学参数。分析SLE患者NLR和PLR与系统性红斑狼疮疾病活动指数(SLEDAI)、免疫、炎症及代谢指标的相关性。结果SLE组的白细胞计数(WBC)、中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、红细胞计数(RBC)、血红蛋白(HGB)、血细胞比容(HCT)、平均红细胞体积(MCV)、血小板计数(PLT)、血小板压积(PCT)低于对照组,红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)高于对照组(P<0.05)。NLR和PLR是与SLE患者密切相关的血液学参数。NLR预测SLE的曲线下面积(AUC)为0.84,灵敏度为90.29%,特异度为74.68%;PLR预测SLE的AUC为0.74,灵敏度为82.52%,特异度为57.28%。相关性分析显示,NLR与SLEDAI、免疫球蛋白G(IgG)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、红细胞沉降率(ESR)、三酰甘油(TG)、总胆固醇(TC)、尿酸(UA)呈正相关,与补体C3、补体C4、低密度脂蛋白胆固醇(LDL-C)和白蛋白(ALB)呈负相关(P<0.05);PLR与SLEDAI、IgG、CRP、IL-6、ESR、TG、TC、高密度脂蛋白胆固醇(HDL-C)和UA呈正相关,与ALB呈负相关(P<0.05)。结论NLR、PLR可作为评估SLE患者疾病活动程度、免疫、炎症及代谢功能状态的一种简便工具,具有重要的临床应用价值。Objective To explore the clinical application value of hematological parameters in the occurrence and development of systemic lupus erythematosus(SLE).Methods Two hundred and seventy-eight SLE patients diagnosed in our hospital from January 2012 to December 2020 were selected as SLE group,and 278 healthy subjects who underwent physical examination in our hospital during the same period were selected as control group.The characteristic hematological parameters related to SLE were screened out.The correlation of NLR and PLR with Systemic Lupus Erythematosus Disease Activity Index(SLEDAI),immune,inflammatory and metabolic indexes in SLE patients was analyzed.Results The white blood cell count(WBC),neutrophil count(NEU),lymphocyte count(LYM),red blood cell count(RBC),hemoglobin(HGB),hematocrit(HCT),mean corpuscular volume(MCV),platelet count(PLT)and plateletcrit(PCT)in the SLE group were lower than those in the control group,the red blood cell distribution width(RDW),neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)were higher than those in the control group(P<0.05).NLR and PLR were hematological parameters closely related to SLE patients.The areas under the curve(AUC)of NLR in predicting SLE was 0.84,the sensitivity was 90.29%,and the specificity was 74.68%,the AUC of PLR in predicting SLE was 0.74,the sensitivity was 82.52%,and the specificity was 57.28%.Correlation analysis showed that NLR were positively correlated with SLEDAI,immunoglobulin G(IgG),C-reactive protein(CRP),interleukin-6(IL-6),erythrocyte sedimentation rate(ESR),triglyceride(TG),total cholesterol(TC),uric acid(UA),and negatively correlated with complement C3,complement C4,low-density lipoprotein cholesterol(LDL-C)and albumin(ALB)(P<0.05);PLR was positively correlated with SLEDAI,IgG,CRP,IL-6,ESR,TG,TC,high-density lipoprotein cholesterol(HDL-C)and UA,and negatively correlated with ALB(P<0.05).Conclusion NLR and PLR can be used as a simple tool to evaluate the degree of disease activity,immune,inflammatory and metabolic function of

关 键 词：血液学参数 系统性红斑狼疮 免疫指标 炎症指标 

分 类 号：R593.241[医药卫生—内科学]