甲状腺功能检测在妊娠期孕产妇中的应用价值  

Application value of thyroid function test in pregnant and lying-in women during gestation period

作　　者：牟艳玲 柏莹[2] 张益萌 MOU Yanling;BAI Ying;ZHANG Yimeng(Nanzheng District People's Hospital,Hanzhong 723100;Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]南郑区人民医院,陕西汉中723100 [2]汉中市中心医院,陕西汉中723000

出　　处：《临床医学研究与实践》2023年第22期125-128,共4页Clinical Research and Practice

摘　　要：目的探讨甲状腺功能检测在妊娠期孕产妇中的应用价值。方法选取2020年4月至2021年5月68例接受孕检的孕产妇作为观察组,同时选取同期68例接受健康体检的未妊娠女性作为对照组,两组均接受甲状腺功能检测。比较两组的甲状腺功能异常情况、甲状腺功能指标;比较观察组中正常妊娠组、妊娠期伴甲状腺功能异常组的凝血、内皮、抗凝血及纤溶指标。结果观察组的甲状腺功能异常总发生率为29.41%,高于对照组的13.24%(P<0.05)。观察组的甲状腺素(T4)、游离甲状腺素(FT4)水平均高于对照组(P<0.05)。妊娠期伴甲状腺功能异常组的凝血酶-抗凝血酶复合物(TAT)、D-二聚体(D-D)及血管性血友病因子抗原(vWF∶Ag)水平均高于正常妊娠组(P<0.05)。妊娠期伴甲状腺功能异常组的血浆蛋白C活性(PC∶A)、抗凝血酶活性(AT∶A)、游离蛋白S活性(FPS∶A)及组织型纤溶酶原激活物活性(t-PA∶A)水平均低于正常妊娠组,纤溶酶原激活物抑制物活性(PAI∶A)水平高于正常妊娠组(P<0.05)。结论甲状腺功能检测能够及时发现妊娠期孕产妇甲状腺功能异常状态,有效评估孕妇血管内皮功能状况及妊娠期血栓倾向。Objective To explore the application value of thyroid function test in pregnant and lying-in women during gestation period.Methods From April 2020 to May 2021,68 pregnant and lying-in women who received pregnancy test were selected as observation group,and 68 non-pregnant women who underwent physical examination during the same period were selected as control group.Both groups received thyroid function test.The thyroid dysfunction and thyroid function indexes of the two groups were compared;the coagulation,endothelial anticoagulation and fibrinolysis indexes of normal pregnancy group and pregnancy with thyroid dysfunction group in the obsevation group were compared.Results The total incidence of thyroid dysfunction in the observation group was 29.41%,which was higher than 13.24%in the control group(P<0.05).The levels of thyroxine(T4)and free thyroxine(FT4)in the observation group were higher than those in the control group(P<0.05).The levels of thrombin-antithrombin complex(TAT),D-dimer(D-D)and von Willebrand factor antigen(vWF∶Ag)in the pregnancy with thyroid dysfunction group were higher than those in the normal pregnancy group(P<0.05).The protein C activit(PC∶A),antithrombin(AT∶A),free protein S activity(FPS∶A)and tissue type plasminogen activator activity(t-PA∶A)level in the pregnancy with thyroid dysfunction group were lower than those in the normal pregnancy group,and plasminogen activator inhibitor activity(PAI∶A)level was higher than that in the normal pregnancy group(P<0.05).Conclusion Thyroid function test can timely detect the abnormal thyroid function of pregnant and lying-in women during gestation period,and effectively evaluate the vascular endothelial function of pregnant women and the thrombosis tendency during gestation period.

关 键 词：孕产妇 甲状腺功能检测 甲状腺疾病 血管内皮功能 血栓倾向 

分 类 号：R714.12[医药卫生—妇产科学]