黄术灌肠液治疗重症急性胰腺炎肠功能障碍的临床观察  

Clinical observation on the treatment of intestinal dysfunction in severe acute pancreatitis with Huangzhu water enema

作　　者：庄李磊[1] 陆小锋 金志清[1] 王海英[1] 雷鑫明 胡团敏[3] ZHUANG Lilei;LU Xiaofeng;JIN Zhiqing;WANG Haiying;LEI Xinming;HU Tuanmin(Department of Gastroenterology,Yiwu Central Hospital,Yiwu 322000,Zhejiang,China;Department of Gastroenterology,People’s Hospital of Quzhou,Quzhou 324000,Zhejiang,China;Department of Gastroenterology,910th Hospital of the Joint Service Support Force of the People’s Liberation Army,Quanzhou 362000,Fujian,China)

机构地区：[1]义乌市中心医院消化内科,浙江义乌322000 [2]衢州市人民医院消化内科,浙江衢州324000 [3]中国人民解放军联勤保障部队第九一〇医院消化内科,福建泉州362000

出　　处：《中国现代医生》2023年第21期73-76,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2023XY216);义乌市科研计划项目(20-3-034)。

摘　　要：目的 观察黄术灌肠液对重症急性胰腺炎(severe acute pancreatitis,SAP)肠功能障碍的影响。方法 选择义乌市中心医院2020年5月至2022年5月收治的SAP患者58例,按照随机数字表法分为观察组和对照组,每组各29例,两组患者均按指南给予规范化治疗,观察组加用黄术灌肠液治疗。比较两组患者的腹痛、腹胀缓解时间及首次排气时间;体温、白细胞及血液淀粉酶恢复正常时间;血清C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)和白细胞介素-6(interleukin-6,IL-6)治疗前后水平,同时比较两组患者3个月后出现的胰腺假性囊肿、糖尿病例数。结果观察组患者的腹痛、腹胀缓解时间及首次排气时间明显短于对照组(P<0.05);观察组患者的体温、白细胞及血液淀粉酶恢复正常时间显著短于对照组(P<0.05);血清CRP、PCT和IL-6水平与对照组相比,浓度显著下降;且通过随访发现,观察组患者3个月后发生胰腺假性囊肿、糖尿病例数少于对照组。结论 在常规治疗的基础上联合黄术灌肠液对SAP患者进行治疗,可显著改善患者的腹痛腹胀,缩短疾病进程,促进肠道功能恢复,同时降低机体炎症反应,治疗效果及远期预后较好。Objective To observe the effects of Huangzhu water enema in treatment with intestinal dysfunction of severe acute pancreatitis(SAP).Methods A total of 58 patients with SAP admitted to Yiwu Central Hospital from May 2020 to May 2022 were divided into observation group and control group by random number table method,with 29 cases in each group,and the patients in both groups were given standardized treatment according to the guidelines,and the observation group was treated with Huangzhu water enema.The two groups were compared with abdominal pain,time to relief of abdominal distension and time to first exhaust;Normal time for body temperature,leukocytes and blood amylase to return to normal;Serum C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6)levels before and after treatment,and the number of pancreatic pseudocysts and diabetes mellitus after 3 months in the two groups was compared.Results The time to relieve abdominal pain,bloating and first exhaust movement in observation group was significantly shorter than that in control group(P<0.05),the recovery time of body temperature,leukocytes and blood amylase in observation group was significantly shorter than that in control group(P<0.05),and the serum CRP,PCT and IL-6 levels decreased significantly compared with control group.Through follow-up,it was found that pancreatic pseudocyst occurred 3 months later in observation group,and the number of diabetes cases was less than that in control group.Conclusion On the basis of conventional treatment,combined with Huangzhu water enema for the treatment of patients with SAP,it significantly improved abdominal pain and bloating,shortened the disease process,promoted the recovery of intestinal function,and reduced the body’s inflammatory response,and the treatment effect and long-term prognosis were good.

关 键 词：重症急性胰腺炎 肠功能障碍 黄术灌肠液 

分 类 号：R657.51[医药卫生—外科学]