HIV/AIDS患者抗病毒治疗前睡眠障碍现况及影响因素  

Prevalence and influencing factors of sleep disorder in HIV/AIDS patients before antiviral therapy

作　　者：冯理智 刘波[1] 赵涵[1] 刘新华[1] 郑丹娜 杜佩珊 何浩岚 Feng Lizhi;Liu Bo;Zhao Han;Liu Xinhua;Zheng Danna;Du Peishan;He Haolan(Infectious Diseases Center of the Eighth Affiliated City Hospital of Guangzhou Medical University,Guangzhou 510060,China)

机构地区：[1]广州医科大学附属市八医院感染病中心,广州510060

出　　处：《中国医师杂志》2023年第7期1016-1019,共4页Journal of Chinese Physician

基　　金："十三五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2017ZX10202102-004-001);市校(院)联合资助项目基础与应用基础研究项目(202201020253)。

摘　　要：目的了解HIV/AIDS患者抗病毒治疗前睡眠障碍的发生率,并探讨其风险因素。方法随机抽取2016年1月至6月在广州医科大学附属市八医院就诊的200例初治HIV/AIDS患者,根据匹兹堡睡眠质量指数问卷(PSQI)分为睡眠良好组、睡眠障碍组,收集两组患者的基础资料和抗病毒治疗前焦虑抑郁情况,应用单因素分析和多因素logistic回归分析HIV/AIDS患者睡眠障碍的影响因素。结果200例HIV/AIDS患者抗病毒治疗前睡眠障碍发生率为22.5%(45/200);CD4+T细胞计数为(414.13±202.16)个/μl,其中29%(58/200)的患者CD4+T细胞计数<200个/μl。睡眠良好组、睡眠障碍组患者CD4+T细胞计数及合并梅毒感染、共病焦虑、共病抑郁比例差异有统计学意义(均P<0.05)。多因素logistic回归分析结果显示,合并梅毒感染(OR=4.606;95%CI:1.973~10.752;P<0.001)、共病焦虑(OR=2.496;95%CI:1.086~5.737;P=0.031)和共病抑郁(OR=2.087;95%CI:0.915~4.760;P=0.040)是HIV/AIDS患者抗病毒治疗前睡眠障碍的危险因素。结论广州市HIV/AIDS患者抗病毒治疗前睡眠障碍发生率较高,合并梅毒感染、共病焦虑和共病抑郁时尤为突出。应对HIV/AIDS患者的睡眠障碍进行早期评估和检测,采取多种方式进行干预,提高睡眠质量。Objective To understand the incidence of sleep disorder in human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)patients before antiviral therapy,and to explore its risk factors.Methods 200 newly treated HIV/AIDS patients who visited the Eighth Affiliated City Hospital of Guangzhou Medical University from January to June 2016 were randomly selected.According to the Pittsburgh Sleep Quality Index(PSQI),they were divided into a good sleep group and a Sleep disorder group;The influencing factors of sleep disorder in HIV/AIDS patients were analyzed by univariate analysis and multivariate logistic regression.Results The incidence of Sleep disorder in 200 HIV/AIDS patients before antiviral therapy was 22.5%(45/200);CD4+T cell count was(414.13±202.16)/μl;29%(58/200)of patients had CD4+T cell counts<200/μl.There were significant differences in CD4+T cell count and the proportion of patients with syphilis infection,comorbidity anxiety and comorbidity depression between the good sleep group and the Sleep disorder group(all P<0.05).Multivariate logistic regression analysis showed that syphilis infection(OR=4.606;95%CI:1.973-10.752;P<0.001),comorbidity anxiety(OR=2.496;95%CI:1.086-5.737;P=0.031)and comorbidity depression(OR=2.087;95%CI:0.915-4.760;P=0.040)were risk factors for sleep disorder in HIV/AIDS patients before antiviral treatment.Conclusions The incidence of Sleep disorder in HIV/AIDS patients before antiviral therapy in Guangzhou is high,especially in patients with syphilis infection,comorbidity anxiety and comorbidity depression.The sleep disorder of HIV/AIDS patients should be assessed and detected early,and multiple interventions should be taken to improve sleep quality.

关 键 词：HIV感染 获得性免疫缺陷综合征 睡眠障碍 

分 类 号：R512.91[医药卫生—内科学] R740[医药卫生—临床医学]